Image of DISTRIBUSI POLIMOFISME TITIK -2849 PROMOTER GEN IL-10 PADA PASIEN KUSTA DI RSUP DR. MOHAMMAD HOESIN PALEMBANG

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DISTRIBUSI POLIMOFISME TITIK -2849 PROMOTER GEN IL-10 PADA PASIEN KUSTA DI RSUP DR. MOHAMMAD HOESIN PALEMBANG

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Leprosy is a chronic granulomatous disease. Leprosy is caused by M. leprae. However, not all exposure to M. leprae caused the disease. The condition of the host immune system determines the pathogenesis of leprosy. IL-10 work as a pro- and anti-inflammatory cytokine. Polymorphism in the IL-10 gene promoter affects the amount of IL-10 secretion. The amount of IL-10 secretion determines the body’s responses to M. leprae. The purpose of this study was to determine the distribution of -2849 IL-10 gene promoter polymorphism in leprosy patient at RSUP dr. Mohammad Hoesin Palembang. This research is an observational descriptive study with cross sectional design. Polymorphism identification was performed using PCR-RFLP and Nested. A total of 49 samples were identified. Most of the leprosy patients at RSUP dr. Mohammad Hoesin for the period January – February were < 50 years old (73.47%), male (65.30%), MB leprosy (91.84%), and came from Malay-South Sumatra ethnicity (53.06%). The genotype frequency distribution was GG 93.88%, AG 6.12%, and AA 0%. The frequency of allele G was 96.94% and allele A 3.06%. The majority of leprosy patients at RSUP dr. Mohammad Hoesin had wild-type genotypes. Keywords: leprosy, polymorphism, IL-10, -2849

Availability
Inventory Code Barcode Call Number Location Status
2107000633T40207T402072021Central Library (REFERENCES)Available but not for loan - Not for Loan
Detail Information
Series Title
-
Call Number
T402072021
Publisher
Palembang : Prodi Kedokteran, Fakultas Kedokteran Universitas Sriwijaya.,
Collation
xiii, 103 hlm.: Ilus., tab.; 29 cm
Language
Indonesia
ISBN/ISSN
-
Classification
616.507
Content Type
Text
Media Type
unmediated
Carrier Type
unspecified
Edition
-
Subject(s)
Kedokteran
Kusta-Penyakit
Specific Detail Info
-
Statement of Responsibility
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No other version available

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