Skripsi

PENGARUH GEL EKSTRAK KULIT BATANG DUKU (LANSIUM DOMESTICUM) TERHADAP PENYEMBUHAN ULSER PADA TIKUS GALUR WISTAR

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Penilaian

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Background: Ulcer is one of the common lesion in oral mucosa. Ulcer could be treated with topical drugs, but prolonged use of topical drugs could induced several side effect, so alternative drugs from herbal plant could be used, such as duku stem bark (Lansium domesticum). Duku stem bark contains flavonoid, saponin, alkaloid, and triterpenoid that increased healing process. This study was to determine the effect of duku stem bark extract gel on healing of wistar strain rats’ ulcer. Method: An in vivo experimental research study with pretest posttest only control group design was done. Total sample of 25 wistar strain rats were divided into 5 tested groups: group 5%, 10%, and 20% duku stem bark extracts gel, 0,1% triamcinolone acetonide as positive control group, and placebo gel as negative control group. The ulcers were induced at the lower lip mucosa of rats by applicating 3% hydrogen peroxide. Extract gels were applied to the ulcers 3 times a day for 14 days. Diameter of ulcer was measured on day 0,3,5,7,9,11,13, and 14 using the UNC-15 probe (mm). Data were analyzed using Kruskal Wallis and, Pairwise Comparison test. Result: This study showed that 20% duku stem baBackground: Ulcer is one of the common lesion in oral mucosa. Ulcer could be treated with topical drugs, but prolonged use of topical drugs could induced several side effect, so alternative drugs from herbal plant could be used, such as duku stem bark (Lansium domesticum). Duku stem bark contains flavonoid, saponin, alkaloid, and triterpenoid that increased healing process. This study was to determine the effect of duku stem bark extract gel on healing of wistar strain rats’ ulcer. Method: An in vivo experimental research study with pretest posttest only control group design was done. Total sample of 25 wistar strain rats were divided into 5 tested groups: group 5%, 10%, and 20% duku stem bark extracts gel, 0,1% triamcinolone acetonide as positive control group, and placebo gel as negative control group. The ulcers were induced at the lower lip mucosa of rats by applicating 3% hydrogen peroxide. Extract gels were applied to the ulcers 3 times a day for 14 days. Diameter of ulcer was measured on day 0,3,5,7,9,11,13, and 14 using the UNC-15 probe (mm). Data were analyzed using Kruskal Wallis and, Pairwise Comparison test. Result: This study showed that 20% duku stem bark extract gel had significant effect in ulcer diameters on day 13 compared to other group (p

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2107000609	T41104	T411042021	Central Library (REFERENCES)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T411042021

Publisher

Palembang : Prodi Kedokteran Gigi dan Mulut, Fakultas Kedokteran Universitas Sriwijaya., 2021

Collation

xiv, 48 hlm.; tab.; ilus.; 29 cm.

Language

Indonesia

ISBN/ISSN

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Classification

615.307

Content Type

Text

Media Type

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Carrier Type

-

Edition

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Subject(s)

Kedokteran Gigi dan Mulut
Ekstrak Kulit Batang Duku

Specific Detail Info

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Statement of Responsibility

MI

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