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UJI EFEKTIVITAS EKSTRAK BAWANG PUTIH (ALLIUM SATIVUM L.) TERHADAP KADAR MDA SERUM TIKUS YANG DIINDUKSI ASAP ROKOK

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Penilaian

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Background: Cigarettes are one of the leading causes of death worldwide. The number of deaths caused by exposure to cigarette smoke reaches 8 million individuals per year. This can occur because cigarette smoke contains more than 7,000 chemical compounds that can cause damage to body cells due to high levels of reactive oxygen species (ROS), thereby increasing oxidative stress that triggers lipid peroxidation and produces MDA products used as biomarkers of oxidative stress. Garlic is known as one of the herbal plants that has natural antioxidant properties because it contains high levels of phytochemicals and organosulfur compounds. This study aims to determine the effectiveness of garlic extract administration in reducing serum MDA levels in Wistar rats. Methods: This study was an in vivo experimental study using a posttest-only controlled group design. This study used 30 male white rats (Rattus novergicus) of the Wistar strain, which were divided into 6 groups, namely the control group, cigarette smoke induction group, vitamin C group, EBP 50 group, EBP 100 group, and EBPC 100 group, with 5 Wistar rats in each group. Each group was exposed to 2 cigarettes for 1 hour every day and administered garlic extract using a sonde for a total of 21 days. Blood serum was collected from the ophthalmic vein, and MDA levels were measured using the TBARS method. The research data were analyzed using the Kruskal-Wallis and Mann-Whitney U tests in SPSS Statistics 24. Results: Cigarette smoke induction increased MDA levels in rat blood serum. Administration of garlic extract at doses of 50 mg/kg BW, 100 mg/kg BW, and a combination of garlic extract and vitamin C did not significantly reduce MDA levels. Conclusion: Garlic extract did not have a significant effect on the increase in MDA levels in the blood serum of Wistar rats.

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2507006681	T186784	T1867842025	Central Library (Reference)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T1867842025

Publisher

Palembang : Prodi Pendidikan Kedokteran, Fakultas Kedokteran Universitas Sriwijaya., 2025

Collation

xvi, 92 hlm.; ilus.; tab.; 29 cm.

Language

Indonesia

ISBN/ISSN

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Classification

615.320 7

Content Type

Text

Media Type

unmediated

Carrier Type

other (computer)

Edition

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Subject(s)

Prodi Pendidikan Kedokteran
Tumbuhan Obat--Bawang Putih

Specific Detail Info

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Statement of Responsibility

MI

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