Skripsi

EFEKTIVITAS EKSTRAK DAUN KERSEN (Muntingia calabura L.) DALAM MEMPERTAHANKAN KADAR REACTIVE OXYGEN SPECIES (ROS) TIKUS WISTAR MODEL GOUT ARTRITIS AKUT

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Penilaian

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Gout arthritis is an inflammatory joint condition caused by uric acid crystal accumulation. The inflammatory mechanism involves complex pathways that increase Reactive Oxygen Species (ROS) levels. Muntingia calabura L. leaves contain bioactive compounds, such as flavonoids, which are known to reduce ROS production by mitigating pro-inflammatory signaling pathways. This study aims to evaluate the effectiveness of Muntingia calabura L. leaf extract as an anti-inflammatory and antioxidant agent in maintaining ROS levels in Wistar rats with acute gout arthritis. An in vivo experimental study was conducted using Wistar rats (Rattus norvegicus) at the Faculty of Medicine, Universitas Sriwijaya, from August to November 2024. Thirty rats were randomly divided into five groups. Four treatment groups received colchicine (0.3 mg/kgBW) or EDK (50, 100, and 200 mg/kgBW) orally for seven days. One hour after the final dose, monosodium urate (MSU) crystals were injected intra-articularly into the right knee joint. Inflammatory symptoms were assessed at 6, 24, 48, and 72 hours post-induction. ROS levels in joint tissue were measured using ELISA after 72 hours. The data were processed and analyzed using SPSS 27.0 for Windows. The 50 mg/kgBW dose of Muntingia calabura L. extract significantly maintained ROS levels compared to the negative control (Paired t-test, p

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2407006659	T160179	T1601792024	Central Library (REFERENCE)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T1601792024

Publisher

Indralaya : Prodi Pendidikan Kedokteran, Fakultas Kedokteran Universitas Sriwijaya., 2024

Collation

xiv, 58 hlm.; ilus.; 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

615.320 7

Content Type

Text

Media Type

unmediated

Carrier Type

-

Edition

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Subject(s)

Prodi Pendidikan Kedokteran
Obat herbal – Aktivitas antioksidan

Specific Detail Info

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Statement of Responsibility

TUTI

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