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HUBUNGAN ANTARA DIABETES DENGAN KEGAGALAN PENGOBATAN TUBERCULOSIS DI ASIA: SYSTEMATIC REVIEW DAN META-ANALISIS

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Globally, tuberculosis (TB) remains a major public health problem, especially in developing countries, where the increasing number of untreated TB patients can lead to higher mortality rates. The rising prevalence of diabetes is a factor of increasing focus in the context of the increased risk of TB infection and treatment failure. This study aimed to investigate the impact of diabetes mellitus on TB treatment outcomes in Asia. A systematic review and meta-analysis methodology was employed. In the meta-analysis, pooled analysis, subgroup analysis, sensitivity analysis, and publication bias test were performed using RevMan 5.3 software. A Literature search yielded 24 studies that were included in the systematic review and meta-analysis. The pooled analysis results showed a significant effect and a 1.30fold increased risk of diabetes mellitus on unfavorable or failed TB treatment outcomes in Asia (OR: 1.30; 95% CI: 1.11-1.52). Subgroup analysis results in the age group >18 years showed a 1.87-fold increased risk of treatment failure in TBDM patients (OR:1.87; 95% CI: 0.97-3.60). The meta-analysis results, which concluded that diabetes has an impact on TB treatment failure in Asia, highlight the need for further interventions such as healthy lifestyle changes to manage diabetes in TB patients as a factor influencing TB treatment outcomes in Asia and for better TB-DM treatment guidelines, especially in countries with a high TB burden.

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Inventory Code Barcode Call Number Location Status
2407005277T155578T1555782024Central Library (References)Available but not for loan - Not for Loan
Detail Information
Series Title
-
Call Number
T1555782024
Publisher
Indralaya : Prodi Kesehatan Masyarakat, Fakultas Kesehatan Masyarakat Universitas Sriwijaya.,
Collation
xv, 78 hlm.; ilus.; tab, 29 cm.
Language
Indonesia
ISBN/ISSN
-
Classification
614.407
Content Type
Text
Media Type
unmediated
Carrier Type
other (computer)
Edition
-
Subject(s)
Prodi Kesehatan Masyarakat
Timbulnya, Penyebaran dan Pengawasan Penyakit
Specific Detail Info
-
Statement of Responsibility
Other version/related
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