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PENGARUH VOLUME CAIRAN RESUSITASI TERHADAP INFLAMASI, NEKROPTOSIS, DAN MORTALITAS PADA MODEL TIKUS SEPSIS Analisis terhadap marker inflamasi (IL-6, TNF-α, dan CRP) dan MLKL (mixed-lineage kinase domain-like)

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Introduction: Sepsis remains a leading cause of mortality in intensive care units. Fluid resuscitation is the cornerstone of management; however, excessive volume may exacerbate inflammation, activate necroptosis, and aggravate organ injury. This study aimed to evaluate the effect of different fluid resuscitation volumes on inflammation, necroptosis, and renal injury in a lipopolysaccharide (LPS)-induced sepsis rat model. Method: An experimental post-test only control group design was conducted on 30 male Wistar rats divided into six groups (K1–P4). Following LPS induction at 10 mg/kgBW intraperitoneally, rats received 0.9% NaCl at volumes of 0, 15, 30, and 60 mL/kgBW. Serum levels of IL-6, TNF-α, CRP, and MLKL were measured using ELISA; renal pMLKL expression was evaluated by immunohistochemistry; and kidney tissue injury was assessed by H&E staining with semi-quantitative scale. Data were analyzed using ANOVA, Kaplan–Meier survival analysis, regression, and PLS-SEM structural modeling. Result: The 15 mL/kgBW group demonstrated the lowest levels of IL-6 (2.74 ± 0.54 ng/mL), TNF-α (65.25 ± 9.64 ng/mL), CRP (0.98 ± 0.12 mg/L), MLKL (644.59 ± 58.06 ng/mL), pMLKL (3.40 ± 0.40), and kidney injury score (1.76 ± 0.11) (p

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Inventory Code Barcode Call Number Location Status
2507006430T185950T1859502025Central Library (Reference)Available but not for loan - Not for Loan
Detail Information
Series Title
-
Call Number
T1859502025
Publisher
Palembang : Program Studi Sains Biomedis Program Doktor Fakultas Kedokteran Universitas Sriwijaya.,
Collation
xxiii, 175 hlm.; ilus.; tab.; 29 cm.
Language
Indonesia
ISBN/ISSN
-
Classification
610.280 7
Content Type
Text
Media Type
unmediated
Carrier Type
other (computer)
Edition
-
Subject(s)
Program Studi Sains Biomedis Program Doktor
Pengobatan Ilmu Biomedis
Specific Detail Info
-
Statement of Responsibility
Other version/related
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