Skripsi

PROFIL FUNGSI JANTUNG PADA ANAK LEUKEMIA LIMFOBLASTIK AKUT DENGAN KEMOTERAPI ANTRASIKLIN DI RS MOHAMMAD HOESIN PALEMBANG

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Penilaian

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Acute lymphoblastic leukemia (ALL) is a hematological malignancy that frequently occurs in children, with a peak incidence between 2–5 years of age. Treatment for ALL often involves chemotherapy using anticancer drugs to destroy cancer cells. One commonly used drug class is anthracyclines, which are known for their cardiotoxic effects. Anthracycline-induced cardiotoxicity can damage the heart muscle, leading to impaired cardiac function. This study aimed to determine the cardiac function profile of children with ALL undergoing anthracycline chemotherapy at Mohammad Hoesin Hospital, Palembang. This was a descriptive observational study with a cross-sectional design. Subjects were selected using a consecutive sampling technique. Primary data were obtained through interviews and echocardiographic examinations. Data analysis was conducted using SPSS version 27.0 and presented in the form of frequency distributions. The study included 31 subjects. Most patients were in the age group of 1– 10 years (64.5%), were male (71%), had good nutritional status (71%), were classified as high-risk ALL (74.2%), were in the maintenance phase (51.6%), had treatment durations > 7 weeks (64.5%), used the anthracycline daunorubicin (100%), and had cumulative doses ≥ 120 mg/m2 (58,1%). Echocardiographic profiles showed LVEF > 55% (100%), LVFS ≥ 28% (100%), MV E/A ratio of 1.5– 2.3 (64.5%), TAPSE ≥ 15 mm (100%). Findings of heart abnormalities include minimal pericardial effusion (19.3%) and tricuspid regurgitation (3.2%). All study subjects exhibited normal biventricular systolic function, although some patients demonstrated altered left ventricular diastolic function, including both reductions and increases.

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2407006879	T161832	T1618322024	Central Library (REFERENCE)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T1618322024

Publisher

Indralaya : Prodi Pendidikan Kedokteran, Fakultas Kedokteran Universitas Sriwijaya., 2024

Collation

xiv, 91 hlm.; ilus.; 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

616.120 07

Content Type

Text

Media Type

unmediated

Carrier Type

-

Edition

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Subject(s)

Prodi Pendidikan Kedokteran
Fungsi jantung — Anak — Efek kemoterapi

Specific Detail Info

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Statement of Responsibility

TUTI

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