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PENGGUNAAN KELASI BESI DEFERASIROX DAN PENURUNAN KADAR FERRITIN SERUM PASIEN THALASSEMIA MAYOR ANAK

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Penilaian

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Background: Pediatric thalassemia major require lifelong blood transfusions to compensate inadequate erythrocyte. However, regular blood transfusions cause iron overload. In addition, pathologically in thalassemia, there is also iron accumulation due to faster hemolysis and ineffective erythropoiesis process. Iron overload is toxic for organ so that it must be removed using iron chelation, one of which is deferasirox. This study aims to determine the best dose of deferasirox to reduces serum ferritin in pediatric thalassemia major at Dr. Mohammad Hoesin Hospital Palembang. Methods: This descriptive observational study was conducted at Dr. Mohammad Hoesin Hospital Palembang from October to December 2024. There were 69 samples that met the inclusion criteria from total 208 samples. Data were analyzed using SPSS version 27 in the form of frequency distribution and grouping through ROC Analysis. Results: The characteristics of the samples were mostly in the age group of 10-18 years (49.3%), the majority were diagnosed with thalassemia ≤5 years (71%), and the majority had blood transfusions ≥12 times/year (59.4%). The greatest decrease in serum ferritin in the 31-40 mg/kg/day dose group (6.710.2µg/L), however, the number of samples who experienced a decrease in serum ferritin levels was greatest using the 21-30 mg/kg/day dose (57,8%) of the total samples that experienced a decrease ferritin serum Conclusion: The use of deferasirox doses in pediatric thalassemia major at Dr. Mohammad Hoesin Palembang Hospital which experienced the most decline was at a dose of 21-30 mg/kg/day. Keywords: Thalassemia, deferasirox, ferritin

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2407006858	T161388	T1613882024	Central Library (REFERENCE)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T1613882024

Publisher

Indralaya : Prodi Pendidikan Kedokteran, Fakultas Kedokteran Universitas Sriwijaya., 2024

Collation

ix, 86 hlm.; ilus.; 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

616.152 07

Content Type

Text

Media Type

unmediated

Carrier Type

-

Edition

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Subject(s)

Prodi Pendidikan Kedokteran
Thalassemia Mayor - Terapi Kelasi Besi

Specific Detail Info

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Statement of Responsibility

TUTI

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