Skripsi

ANALISIS AKTIVITAS ENZIM KOLINESTERASE DENGAN KEJADIAN HIPERTENSI PADA PETANI PADI DI WILAYAH KECAMATAN PEMULUTAN TAHUN 2025

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Penilaian

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Organophosphate and carbamate compounds contained in pesticides can reduce cholinesterase levels by inhibiting the activity of the enzyme acetylcholinesterase (AChE). This inhibition causes the accumulation of acetylcholine in the synaptic cleft, which subsequently triggers vasoconstriction, increased heart rate, and elevated blood pressure. The purpose of this research was to analyze the relationship between cholinesterase enzyme activity and the incidence of hypertension among rice farmers in the Pemulutan District in 2025. This research applied cross-sectional design with purposive sampling and a sample size of 54 rice farmer respondents. Data collection in this research was conducted through observation, interviews, hypertension measurement using an OMRON HEM-7124 digital tensiometer, and examination of cholinesterase enzyme levels using the butyrylthiocholine method with a Roche Cobas C-501 device. Data analysis was conducted using univariate analysis, bivariate analysis with the chi-square test, and multivariate analysis using multiple logistic regression in a risk factor model. Based on the analysis results, several variables were found to be associated with the incidence of hypertension, including: age (p-value=0.001)), spray frequency (p-value=0.000), number of pesticide types (p-value=0.001), and use of personal protective equipment (PPE) (p-value=0.000). The variables not associated with hypertension are gender, length of service and history of hypertension. Multivariate analysis results suggested that there was no relationship between cholinesterase enzyme levels and the incidence of hypertension, and the most influential factor affecting the relationship between cholinesterase levels and the incidence of hypertension is the use of APD with a p-value of 0.047; PR 8.141; 95% Cl = 1.447-148.217. This research concluded that there is no a significant relationship between cholinesterase levels and the incidence of hypertension among rice farmers in the Pemulutan District in 2025.

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2507006131	T183988	T1839882025	Central Library (Reference)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T1839882025

Publisher

Indralaya : Prodi Kesehatan Lingkungan, Fakultas Kesehatan Masyarakat Universitas Sriwijaya., 2025

Collation

xv, 151 hlm.; ilus.; tab.; 29 cm.

Language

Indonesia

ISBN/ISSN

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Classification

616.130 7

Content Type

Text

Media Type

unmediated

Carrier Type

other (computer)

Edition

-

Subject(s)

Hipertensi
Prodi Kesehatan Lingkungan

Specific Detail Info

-

Statement of Responsibility

MI

Other version/related

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