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UJI AKTIVITAS ANTIOKSIDAN EKSTRAK DAN FRAKSI HERBA SIRIH CINA (peperomia pellucida L.) PADA TIKUS WISTAR YANG DIINDUKSI CCl4

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Chinese betel leaf (peperomia pellucida) contains secondary metabolite compounds such as flavonoids and terpenoids that have potential as antioxidants. This study aims to determine the effect of giving extracts and fractions of Chinese betel herb invivo on male Wistar rats induced oxidative stress by carbon tetrachloride (CCl4). The 30 test animals were divided into 6 treatment groups, namely the normal group (Na-CMC 1), negative group (Na-CMC 1 and CCl4), n-hexane fraction treatment group, ethyl acetate fraction treatment group, ethanol fraction treatment group, and total ethanol extract treatment group. Antioxidant activity test was conducted by measuring plasma malondialdehyde (MDA) levels, catalase enzyme activity of liver tissue, as well as macroscopic observations and liver hispatology. The average MDA levels in the normal, negative, n-hexane fraction, ethyl acetate fraction, ethanol fraction, and total ethanol extract groups were 0.969; 2.635; 0.593; 1.208; 1.389 nmol/mL, respectively. The average catalase enzyme activity in the normal, negative, n-hexane fraction, ethyl acetate fraction, ethanol fraction, and total ethanol extract groups were 26.477; 9.385; 37.706; 46.834; 22.231; 15.776 U/mL respectively. The results showed that the administration of ethyl acetate fraction was able to reduce MDA levels significantly (p

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Inventory Code Barcode Call Number Location Status
2507004961T179567T1795672025Central Library (REFRENCE)Available but not for loan - Not for Loan
Detail Information
Series Title
-
Call Number
T1795672025
Publisher
Indralaya : Prodi Ilmu Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya.,
Collation
xvi, 52 hlm.; ilus.; tab, 29 cm
Language
Indonesia
ISBN/ISSN
-
Classification
615.907
Content Type
Text
Media Type
unmediated
Carrier Type
other (computer)
Edition
-
Subject(s)
Prodi Ilmu Farmasi
Farmakologi eksperimental
Specific Detail Info
-
Statement of Responsibility
Other version/related
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