Skripsi

STUDI IN SILICO EKSTRAK BUNGA KECOMBRANG (Etlingera Elatior) SEBAGAI ANTIBAKTERI Staphylococcus Aureus DENGAN PENDEKATAN MOLECULAR DOCKING

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Penilaian

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Staphylococcus aureus infection is caused by a bacterium that colonizes various organs in the human body, particularly the upper respiratory tract, including the skin, nasal cavity, axilla, and inguinal area. The emergence of antibiotic-resistant S. aureus, known as MRSA and VRSA, presents a significant challenge in the treatment of such infections. Natural products, such as the torch ginger flower (Etlingera elatior), have potential as alternative antibacterial agents. This study aims to explore the major active compounds and their mechanisms of action in combating S. aureus through a molecular docking approach. The phytochemical analysis of torch ginger flower extract was conducted using GC-MS. Targets associated with Etlingera elatior and its antibacterial activity were predicted using the SwissTarget database. To assess the binding affinity between active components and their primary targets, molecular docking analysis was performed using AutoDock Vina. The analysis identified 12 active compounds: Erythritol, Glycerin, 4H-Pyran-4-one, 2,3-dihydro-3,5-dihydroxy-6-methyl, 1-Dodecanol, Dodecanoic acid, 1-Tetradecyl acetate, cis-9-Tetradecen-1-ol, 1-Hexadecanol, n-Hexadecanoic acid, 2,5-Furandione, 3-dodecyl, Dodecyl ester, and Z-11-Pentadecenol, which show potential as therapeutic agents against Staphylococcus aureus infection. The primary protein targets involved in inhibiting or treating S. aureus infection include DHFR (2W9S), PTA (4E4R), and UPPS (4H8E). Molecular docking results demonstrated a strong interaction between dodecanoic acid and UPPS (4H8E), with a binding affinity of -7.644 kcal/mol, indicating that dodecanoic acid forms a stable ligand-receptor complex and holds promise as a therapeutic candidate for Staphylococcus aureus infections.

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2507004729	T18050	T1805082025	Central Library (REFERENS)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T1805082025

Publisher

Indralaya : Prodi Ilmu Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya., 2025

Collation

xvii, 64 hlm.; ilus.; tab, 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

615.330 7

Content Type

Text

Media Type

unmediated

Carrier Type

-

Edition

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Subject(s)

Prodi Ilmu Farmasi
Farmakologi tanaman obat

Specific Detail Info

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Statement of Responsibility

MURZ

Other version/related

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