Skripsi

EFEKTIVITAS FRAKSI AIR DAUN KARAMUNTING (Rhodomyrtus tomentosa (Ait.) Hassk.) TERHADAP EKSPRESI GLUT 2 PADAPANKREAS TIKUS PUTIH (Rattus novergicus) JANTAN GALUR WISTAR MODEL DIABETES MELLITUS

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Penilaian

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Background: Type 2 diabetes mellitus (T2DM) is characterized by impaired glucose metabolism due to insulin resistance and decreased pancreatic β-cell function. One of the key factors in glucose regulation is the expression of GLUT 2, a glucose transporter that functions as a glucose sensor. Although drugs such as pioglitazone can improve insulin sensitivity, they may cause long-term side effects. Therefore, plant-based therapeutic alternatives, such as the leaves of Rhodomyrtus tomentosa, are worth exploring. This study aimed to investigate the effect of the aqueous fraction of Rhodomyrtus tomentosa leaves on GLUT 2 expression in the pancreas of male Wistar rats with a diabetes mellitus model. Methods: An experimental study with a post-test only control group design was conducted using male Wistar rats induced with diabetes. The rats were divided into five groups: three treatment groups receiving the aqueous fraction of R. tomentosa leaves at doses of 100, 200, and 400 mg/kgBW, a positive control group (pioglitazone), and a negative control group. GLUT 2 expression was analyzed using immunohistochemistry and assessed by the H-Score method. Results: The aqueous fraction of R. tomentosa leaves increased GLUT 2 expression in a dose-dependent manner. Doses of 200 and 400 mg/kgBW showed significant increases, with the 400 mg/kgBW group approaching the expression levels of the positive control. In contrast, the 100 mg/kgBW dose resulted in lower expression than the negative control, possibly due to subtherapeutic concentrations of active compounds or the use of stored biological materials. Conclusion: The aqueous fraction of R. tomentosa leaves has the potential to enhance GLUT 2 expression in the pancreas of diabetic rat models, particularly at doses of 200 and 400 mg/kgBW. Further studies are required to elucidate the molecular mechanisms and validate its clinical applicability. Keywords: Rhodomyrtus tomentosa, GLUT 2, type 2 diabetes mellitus, aqueous fraction, Wistar rats.

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2507004725	T174469	T1744692025	Central Library (REFERENS)	Available but not for loan - Not for Loan

Detail Information

Series Title

04112622327002

Call Number

T1744692025

Publisher

Indralaya : Prodi Magister Ilmu Biomedik, Fakultas Kedokteran Universitas Sriwijaya., 2025

Collation

xxiii, 443 hlm.; ilus.; tab.; 29 cm.

Language

Indonesia

ISBN/ISSN

-

Classification

610.280 7

Content Type

Text

Media Type

unmediated

Carrier Type

-

Edition

-

Subject(s)

Ilmu Biomedik

Specific Detail Info

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Statement of Responsibility

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Other version/related

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