Image of ISOLASI SENYAWA GOLONGAN FLAVONOID DARI FRAKSI n-HEKSANA DAUN TUMBUHAN LABAN (Vitex pinnata) SERTA UJI SITOTOKSIK TERHADAP LARVA UDANG (Artemia salina)

Skripsi

ISOLASI SENYAWA GOLONGAN FLAVONOID DARI FRAKSI n-HEKSANA DAUN TUMBUHAN LABAN (Vitex pinnata) SERTA UJI SITOTOKSIK TERHADAP LARVA UDANG (Artemia salina)

Penilaian

0,0

dari 5
Penilaian anda saat ini :  

The research was isolated secondary metabolite compounds from the n-hexane fraction of laban plant leaves (Vitex pinnata) and conducted cytotoxic tests on shrimp larvae (Artemia salina) which would potentially be used as anticancer drugs. The isolation process was carried out by maceration extraction in methanol solvent, followed by liquid-liquid fractionation using n-hexane and ethyl acetate. Separation of the n-hexane fraction was carried out by Vacum Liquid Chromatography (VLC) and purity testing using TLC with a 3-eluent system. The structure of the isolated compound was determined based on UV and NMR spectroscopy data, while cytotoxic activity was determined by the Brine Shrimp Lethality Test (BSLT) method. The isolated compound was obtained in the form of yellow crystals as much as 10.2 mg. Based on UV and NMR spectroscopy data (1H-NMR and 13C-NMR for 1-D, HSQC and HMBC for 2-D) showed that the isolated compound is a flavonoid compound of the flavonol group, namely the compound 5-hydroxy-3,7,4'-trimethoxyflavone. Cytotoxic test of the isolated compound against A. salina indicated that the isolated compound is cytotoxic with an LC50 value of 46.97 ± 26.03 mg/L.

Availability
Inventory Code Barcode Call Number Location Status
2507004528T180202T1802022025Central Library (REFERENCE)Available but not for loan - Not for Loan
Detail Information
Series Title
-
Call Number
T1802022025
Publisher
Indralaya : Prodi Ilmu Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya.,
Collation
xvi, 125 hlm.; ilus.; tab.; 29 cm.
Language
Indonesia
ISBN/ISSN
-
Classification
540.07
Content Type
-
Media Type
-
Carrier Type
-
Edition
-
Subject(s)
Kimia
Specific Detail Info
-
Statement of Responsibility
Other version/related

No other version available

File Attachment
Comments
You must be logged in to post a comment