Skripsi

UJI POTENSI HEMOSTASIS EKSTRAK ETANOL DAUN BANDOTAN (Ageratum conyzoides L.) TERHADAP MENCIT JANTAN (Mus musculus)

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Penilaian

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Bandotan leaves (Ageratum conyzoides L.) contain flavonoid and tannin compounds that act as hemostatic agents. This study aims to determine the most optimal hemostasis effect of varying doses of ethanol extract of bandotan leaves on male mice (Mus musculus). This study used five groups of male mice as samples which were divided into negative control group (NaCMC), positive control (tranexamic acid), and three treatment groups with bandotan leaf ethanol extract doses of 100 mg/kgBB, 150 mg/kgBB, and 250 mg/kgBB given orally for 7 days. Hemostasis parameters were measured using bleeding time with the duke method and clotting time with the slide method observed on day 0 and day 8 of the test. The results showed that ethanol extract of bandotan leaves can accelerate the hemostasis effect significantly (p>0.05) with a dose of 250 mg/kgBB showing effectiveness close to the positive control. The hemostasis mechanism of the extract is related to the flavonoid content that can help the platelet blockage process and has a vasoconstrictive mechanism and tannins have properties as astringents that stop bleeding by precipitating blood proteins. This study shows that ethanol extract of bandotan leaves can be used to accelerate the effect of hemostasis. Keywords: bandotan leaf, bleeding time, blood clotting time, duke method and slide method, hemostasis

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2507004006	T177031	T1770312025	Central Library (Reference)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T1770312025

Publisher

Indralaya : Prodi Ilmu Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya., 2025

Collation

xviii, 118 hlm.; ilus.; tab.; 29 cm.

Language

Indonesia

ISBN/ISSN

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Classification

582.120 7

Content Type

Text

Media Type

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Carrier Type

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Edition

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Subject(s)

Farmasi

Specific Detail Info

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Statement of Responsibility

MI

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