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POTENSI ANTIMALARIA METABOLIT SEKUNDER Lansium domesticum TERHADAP ENZIM Plasmodium falsiparum Lactate dehydrogenase (PfLDH) SECARA IN SILICO

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Penilaian

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Malaria is one of the infectious and deadly diseases in the world. If not treated immediately, malaria will develop into more dangerous complications such as severe anemia, organ damage, and death. Plasmodium falsiparum is a serious infection with a high mortality rate and is a type of cerebral malaria. Plasmodium falsiparum lactate dehydrogenase (PfLDH) enzyme is used as one of the potential molecular target enzymes for antimalarials because Plasmodium falsiparum depends on glycolysis to produce energy. Some malaria drugs that have been found such as chloroquine, artemisinin, and the combination of artemisunate with mefloquine have difficulty in treating malaria cases. The native Indonesian plant Lansium domesticum has the potential to be a natural medicinal material for antimalarial, the content of the compounds contained can be antimalarial. antimalarial drug development is carried out with an In-silico approach using certain computational parameters and algorithms to model the interaction between test compounds and target enzymes. In-silico studies include prediction of biological activity of Lansium domesticum compounds as antimalarials, prediction of physicochemical properties, prediction of pharmacokinetic properties, prediction of toxicity properties and prediction of molecular interactions between test compounds and PfLDH target enzyme using molecular docking method. The results obtained, 47 Lansium domesticum compounds have biological activity as antimalarials. Based on physicochemical, pharmacokinetic, and toxicity predictions of 47 compounds, 4 test compounds were obtained, namely is-3-Hexen-1-ol, Aromadendrene, Isoledene, dan Hexadecanoic acid from Lansium domesticum which are safe candidates for antimalarial drugs. In the docking process, the test compounds and the PfLDH enzyme produce binding affinity values and molecular interactions. Hexadecanoic acid test compound produces 3 amino acid bonds namely GLY29, THR97, and HIS195 which are the same as the active side compared to control and natural ligands. Keywords : Antimalarial, Lansium domesticum, PfLDH, Molecular docking, In-silico

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2507001948	T169947	T1699472025	Central Library (Reference)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T1699472025

Publisher

: Prodi Ilmu Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya., 2025

Collation

xviii, M-8 hlm. : ilus. ; tab. ; 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

570.07

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Biologi

Specific Detail Info

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Statement of Responsibility

EM

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