The Sriwijaya University Library

  • Home
  • Information
  • News
  • Help
  • Librarian
  • Login
  • Member Area
  • Select Language :
    Arabic Bengali Brazilian Portuguese English Espanol German Indonesian Japanese Malay Persian Russian Thai Turkish Urdu

Search by :

ALL Author Subject ISBN/ISSN Advanced Search

Last search:

{{tmpObj[k].text}}
Image of UJI STABILITAS DAN PENETRASI SERUM TRANSFERSOM EKSTRAK ETANOL 96% KULIT BAWANG MERAH (ALLIUM CEPA)

Text

UJI STABILITAS DAN PENETRASI SERUM TRANSFERSOM EKSTRAK ETANOL 96% KULIT BAWANG MERAH (ALLIUM CEPA)

Fathurrahman, Wijdan - Personal Name;

Penilaian

0,0

dari 5
Penilaian anda saat ini :  

This study aims to evaluate the stability and penetration of transfersome serum formulated with 96% ethanol extract of red onion skin (Allium cepa). The results of this research are expected to serve as a foundation for developing pharmaceutical products based on natural ingredients for hair care. Red onion skin (Allium cepa) extract contains secondary metabolite compounds, specifically quercetin, which has potential as an antioxidant and stimulator of hair follicle regeneration, but has limitations due to its stability and skin penetration To enhance the delivery of the active compound into the skin, a transfersome system incorporating tween 80 and phospholipon 90G was utilized. Stability testing was conducted following the ICH Q1A(R2) guidelines through accelerated, intermediate, and long-term stability test, along with cycling tests to evaluate the effects of storage temperature fluctuations. The pH stability was also assessed to determine the optimal conditions for the formulation in its liquid state. The results indicated that transfersome serum was more susceptible to degradation than conventional serum, with degradation kinetics following a second-order reaction and a shelf life of approximately 63 days. In vitro penetration testing using a Franz diffusion cell (FDC) with rat skin membrane demonstrated that the transfersome serum exhibited a higher penetration rate than the non-transfersome serum. Kinetic release analysis revealed that the release mechanism followed the Korsmeyer-Peppas model with anomalous transport diffusion. The flux value of the transfersome serum was 0.0037 mg/cm² per hour, which was significantly higher than the flux of the non-transfersome serum at 0.0022 mg/cm² per hour. In conclusion, the formulation of transfersome serum enhances quercetin penetration but the stability requires improvement through formulation modifications.


Availability
Inventory Code Barcode Call Number Location Status
2507001871T169484T1694842025Central Library (Reference)Available but not for loan - Not for Loan
Detail Information
Series Title
-
Call Number
T1694842025
Publisher
: Prodi Ilmu Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya., 2025
Collation
xiv, 63 hlm.; tab.; 29 cm.
Language
Indonesia
ISBN/ISSN
-
Classification
615.407
Content Type
-
Media Type
-
Carrier Type
-
Edition
-
Subject(s)
Farmasi
Specific Detail Info
-
Statement of Responsibility
EM
Other version/related

No other version available

File Attachment
  • UJI STABILITAS DAN PENETRASI SERUM TRANSFERSOM EKSTRAK ETANOL 96% KULIT BAWANG MERAH (ALLIUM CEPA)
Comments

You must be logged in to post a comment

The Sriwijaya University Library
  • Information
  • Services
  • Librarian
  • Member Area

About Us

As a complete Library Management System, SLiMS (Senayan Library Management System) has many features that will help libraries and librarians to do their job easily and quickly. Follow this link to show some features provided by SLiMS.

Search

start it by typing one or more keywords for title, author or subject

Keep SLiMS Alive Want to Contribute?

© 2025 — Senayan Developer Community

Powered by SLiMS
Select the topic you are interested in
  • Computer Science, Information & General Works
  • Philosophy & Psychology
  • Religion
  • Social Sciences
  • Language
  • Pure Science
  • Applied Sciences
  • Art & Recreation
  • Literature
  • History & Geography
Icons made by Freepik from www.flaticon.com
Advanced Search