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OPTIMASI DAN KARAKTERISASI TRANSETOSOM EKSTRAK KULIT MANGGIS (Garcinia mangostana L.) TERPURIFIKASI 90% ALFA MANGOSTIN

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Penilaian

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Mangosteen peel extract (Garcinia mangostana L.) has alpha mangostin compounds that have very strong antioxidant activity. Transethosomes have better vesicle elasticity and penetration levels so that they can increase the effectiveness of alpha mangostin. This study aims to determine the optimum formula of transethosomes from variations of 96% ethanol concentrations of 20% and 40% with tween 80 concentrations of 0.5% and 0.75%. Optimization using the 22 factorial design method with the Design Expert® 13 application with responses of %EE, decrease in %EE, pH, decrease in pH, and viscosity. The optimum formula of transethosomes was characterized, tested for transethosomes morphology, and tested for antioxidant activity. Based on the results of the Design Expert® 13 analysis, optimum formula was found in formula 2 with concentration of 20% ethanol and 0.5% tween 80 with a %EE value of 99.480 ± 0.2626, a decrease in %EE of 0.362 ± 0.1010, pH 7.62 ± 0.1501, a decrease in pH of 0.030 ± 0.0137, and a viscosity of 1.377 ± 0.4980 cP. The characterization results of the optimum transethosome formula obtained a particle size of 225.9 ± 2.193 nm, PDI 0.28 ± 0.026, and a zeta potential of -8.00 ± 0.695 mV. Transethosome has a spherical shape and the purified mangosteen peel extract transethosome 90% alpha mangostin obtained an IC50 value of 70.91 ppm. Based on the results obtained, the optimum formula of transethosome purified mangosteen peel extract 90% alpha mangostin has good characterization results and has strong antioxidant activity. Keywords: alpha mangostin, antioxidant, ethanol 96%, itransethosome, tween 80

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2507001819	T169620	T1696202025	Central Library (Reference)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T1696202025

Publisher

: Prodi Ilmu Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya., 2025

Collation

xii, 41 hlm.; ill.; tab.; 29 cm.

Language

Indonesia

ISBN/ISSN

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Classification

615.407

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Farmasi

Specific Detail Info

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Statement of Responsibility

EM

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