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FORMULASI DAN KARAKTERISASI GEL TRANSETOSOM EKSTRAK KULIT MANGGIS (Garcinia mangostana L.) TERPURIFIKASI 90% ALFA MANGOSTIN DENGAN VARIASI KONSENTRASI GELLING AGENT

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Penilaian

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Mangosteen peel extract contains alpha-mangostin which accelerates wound healing by stimulating fibroblasts, increasing collagen synthesis, and has anti-inflammatory and antimicrobial properties. Alpha-mangostin transethosomes were developed to improve transdermal delivery because of their better skin penetration and high bioavailability. For ease of use, transethosomes are formulated in gel form. This study aims to obtain the alpha-mangostin transethosomes gel formula with the best gelling agent concentration for wound healing. The formulation of transethosomes gel was carried out by combining carbomer 940 gel base with concentration variations of 0.5%; 1%; 1.5%; 2% and 1% PVA. The results of the evaluation of transethosomes gel based on organoleptic, homogeneity, pH, viscosity, spreadability, adhesiveness, and washability tests showed that the best formula was formula 3 with a concentration of carbomer 940 0.1% and 1% PVA. The average results of the characteristics of pH, viscosity, 150 gram spreadability, 100 gram adhesiveness and washability were respectively 6.12 ± 0.010; 2763.65 ± 44.500 cP; 6.90 ± 0.100 cm; 5.31 ± 0.015 s and 8.26 ± 0.305 mL. The stability test of the best formula using the cycling test method showed that the transethosome gel did not experience organoleptic and syneresis changes, but the gel experienced an increase in pH value and a decrease in viscosity and content values. The results of morphological testing using the transmission electron microscopy method showed that the transethosome vesicles in the gel had a spheric al shape. Diffusion testing showed that there was a difference in the percentage produced from the diffusion test between alpha mangostin extract, alpha mangostin transethosome and alpha mangostin transethosome gel with values respectively 11.1584%; 13.4918%; 12.3556% and the three preparations follow the three compartment model or lag model and the significance value obtained is p

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2507001818	T169603	T1696032025	Central Library (Reference)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T1696032025

Publisher

: Prodi Ilmu Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya., 2025

Collation

xii, 73 hlm.; ill.; tab.; 29 cm.

Language

Indonesia

ISBN/ISSN

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Classification

615.407

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Farmasi

Specific Detail Info

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Statement of Responsibility

EM

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