Skripsi

SKRINING SENYAWA METABOLIT SEKUNDER Lansium domesticum Corr. YANG BERPOTENSI SEBAGAI ANTIDIABETIK TERHADAP ENZIM α-glukosidase SECARA IN SILICO

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Penilaian

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Diabetes mellitus is a disease that experiences an increase in the number of sufferers every year with treatment from synthetic ingredients that can cause harmful side effects to the body. Therefore, the discovery of a natural source of materials from Lansium domesticum Corr. that can inhibit the work of the enzyme α-glucosidase has emerged. Inhibition of the action of diabetes enzymes is one of the potential targets in controlling sugar levels. The enzyme α-glucosidase can be done by inhibiting the active side of the enzyme so that it can slow down the digestion and absorption of carbohydrates. Molecular docking can predict the interaction between compounds from Lansium domesticum Corr. and the target protein enzyme α-glucosidase in silico. Therefore, it is important to search for metabolite compounds from Lansium domesticum Corr. that have the potential to be antidiabetic in inhibiting the enzyme α-glucosidase by producing the lowest binding affinity value and a group of compounds from ligands that can bind to receptors are carried out in silico which can be utilized by having physicochemical, pharmacokinetic biological activity and safe from toxicity. It was carried out by an experimental method in silico to obtain the binding affinity interaction between ligands from Lansium domesticum Corr. compounds and α-glucosidase enzyme receptors safely. The resulting 38 secondary metabolite compounds of Lansium domesticum Corr. have biological activity as an antidiabetic by inhibiting the action of the enzyme α-glucosidase. Based on physicochemical, pharmacokinetic, and toxicity predictions from 38 compounds, 4 Lansium domesticum Corr. test compounds were obtained that were safe to be antidiabetic candidates, namely Catechin, Aphanamol II, Spathulenol and Isogemacrene D were able to inhibit the active side of the enzyme α-glucosidase in silico. Keyword: Antidiabetic, Lansium domesticum Corr., α-glucosidase, in silico, Molecular docking.

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2507002384	T171233	T1712332025	Central Library (Reference)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T1712332025

Publisher

Indralaya : Prodi Ilmu Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya., 2025

Collation

xv, 85 hlm.; ilus.; tab.; 29 cm.

Language

Indonesia

ISBN/ISSN

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Classification

547.707

Content Type

Text

Media Type

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Carrier Type

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Edition

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Subject(s)

Metabolit Enzim

Specific Detail Info

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Statement of Responsibility

MI

Other version/related

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