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UJI AKTIVITAS NANOEMULSI MINYAK CENGKEH DAN CREMOPHOR RH-40 PEMBAWA ASAM USNAT TERHADAP PENYEMBUHAN LUKA BAKAR PADA TIKUS WISTAR

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Penilaian

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Lichen is one of the organisms known for its diverse secondary metabolites, one of which is usnic acid. Usnic acid is known to have anti-inflammatory and antibacterial activities to accelerate burn wound healing. This study aims to determine the concentration of clove oil and Cremophor RH-40 from various concentrations to obtain the optimum usnic acid nanoemulsion formula and test its activity in healing burns. The nanoemulsion formula was optimized using the regularar two-level factorial design method analysed with Design Expert 12 software. The optimum formula selected came from the system with a concentration of 3,5% clove oil 10% Cremophor RH-40. Characterization results showed that the formula had a particle size of 223,9 ± 58,18 nm, polydispersity index of 0,37 ± 00,06, and zeta potential 0f -12,67 ± 0,15 mV. Based on data analysis using one-way ANOVA, the results showed that the optimum nanoemulsion formula did not have a significant difference compared to the positive control in burn wound healing activity as evidenced by the recovery percentage of 98,63 ± 0,1% in 12 days. Nanoemulsion has the potential to be developed as a wound healing drug. Keywords: Usnic acid, Cremophor RH-40, Burns, Clove oil, Nanoemulsion

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2507001573	T169044	T1690442025	Central Library (REFERENCES)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T1690442025

Publisher

Indralaya : Prodi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya., 2025

Collation

xvii, 23 hlm.; ilus.; tab.; 29 cm.

Language

Indonesia

ISBN/ISSN

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Classification

582.120 7

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Farmasi
Prodi Farmasi,

Specific Detail Info

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Statement of Responsibility

TUTI

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