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UJI IN SILICO EKSTRAK ETANOL KULIT BUAH DELIMA MERAH (Punica granatum L.) YANG BERKAITAN DENGAN HIPERPIGMENTASI SERTA UJI ANTIOKSIDAN

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Penilaian

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Skin hyperpigmentation occurs due to excessive melanin production, causing certain areas to be darker than the surrounding skin. The use of anti-hyperpigmentation agents such as kojic acid and hydroquinone that work by inhibiting the tyrosinase enzyme can cause to serious side effects. Therefore, safer natural alternatives are needed. This study analyzes the potential of ethanol extract of red pomegranate peel (Punica granatum L.) in related to hyperpigmentation through the In Silico tests with network pharmacology and molecular docking approaches, as well as antioxidant test using the DPPH method. The results of network pharmacology analysis obtained six main proteins in regulation related to hyperpigmentation, namely EGFR, AKT1, FGF2, STAT3, SRC, and TP53. Potential compounds, namely kaempferol, ellagic acid, gallic acid, and oleamide could potentially interact with these proteins. The main signaling pathways, which are involved include PI3K-akt signaling pathway, the MAPK signaling pathway, and the FoxO signaling pathway. The molecular docking results showed that ellagic acid has the highest affinity to AKT1 (binding affinity -10.55 kcal/mol), which is characterized by the presence of hydrogen and hydrophobic bonds on the active side of the protein. The antioxidant activity of the extract showed an IC50 value of 109.503 ppm, classified as a moderate antioxidant category. These results confirm the potential of ethanol extract of red pomegranate peel as a natural antihyperpigmentation agent.

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2507001670	T169222	T1692222025	Central Library (Reference)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T1692222025

Publisher

Indralaya : Prodi Ilmu Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya., 2025

Collation

xviii, 158 hlm.; ilus.; tab.; 29 cm.

Language

Indonesia

ISBN/ISSN

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Classification

582.120 7

Content Type

Text

Media Type

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Carrier Type

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Edition

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Subject(s)

Ekstrak Etanol Mikroalga

Specific Detail Info

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Statement of Responsibility

MI

Other version/related

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