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HUBUNGAN KADAR SOLUBLE PD-1 DAN JUMLAH SEL T CD8+ SERUM DENGAN FASE INFEKSI HEPATITIS B KRONIK PADA PASIEN YANG BELUM MENDAPATKAN TERAPI ANTIVIRAL DI RS MOHAMMAD HOESIN PALEMBANG

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Background: Chronic hepatitis B infection progresses through distinct phases that reflect the dynamic interplay between the hepatitis B virus (HBV) and the host immune system. Exhausted CD8+ T cells are marked by increased PD-1 expression, while soluble PD-1 (sPD-1), a soluble form of the PD-1 receptor, regulates immune responses. Both sPD-1 and CD8+ T cells play critical roles in determining infection phases and characterizing the progression of chronic hepatitis B. This study aims to investigate the relationship between sPD-1 levels and CD8+ T cell counts across different phases of chronic hepatitis B infection. Method: This analytical observational study with a comparison was conducted at Mohammad Hoesin General Hospital, Palembang, from June to November 2024, involving chronic hepatitis B patients who had not received antiviral therapy. sPD-1 levels were measured using the ELISA method, and CD8+ T cell counts were analyzed by flow cytometry. Data were processed using SPSS version 26. Results: Sixty chronic hepatitis B patients met the inclusion criteria. The reactivation phase showed the highest sPD-1 levels (median: 351.8 pg/mL; range: 196–743.4 pg/mL), while the carrier inactive phase had the lowest levels (mean: 214.78 ± 36.05 pg/mL). sPD-1 levels were significantly higher in the reactivation phase compared to the immune tolerant and carrier inactive phase. CD8+ T cell counts were significantly lower (p

Availability
Inventory Code Barcode Call Number Location Status
2507001635T168439T1684392025Central Library (Reference)Available but not for loan - Not for Loan
Detail Information
Series Title
-
Call Number
T1684392025
Publisher
Palembang : Prodi Dokter Spesialis II(Sp-2), Fakultas Kedokteran Universitas Sriwijaya.,
Collation
xv, 95 hlm.; ilus.; tab.; 29 cm.
Language
Indonesia
ISBN/ISSN
-
Classification
616.362 07
Content Type
Text
Media Type
-
Carrier Type
-
Edition
-
Subject(s)
Infeksi Hepatitis
Specific Detail Info
-
Statement of Responsibility
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