Skripsi

UJI AKTIVITAS ANTIHIPERURISEMIA EKSTRAK ETANOL DAUN PACAR KAYU (Lawsonia inermis L.) PADA TIKUS PUTIH JANTAN GALUR WISTAR

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Penilaian

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Lawsonia inermis L. is one of the traditional medicinal plants that are effective as analgesics. The analgesic effect was related to the ability of the substance to reduced uric acid levels (antihyperuricemia). This study aims to determine the antihyperuricemia activity of ethanol extract of L. inermis leaves using male white rats of the Wistar strain induced in hyperuricemia condition. The study began with Extraction of henna leaves by the maceration method using 96% ethanol. The extract then was standardized and tested the antihyperuricemia activity. The antihyperuricemia test used 35 male white rats and divided into 7 groups: normal group, positive group (allupurinol), negative group (Na-CMC), treatment group with extract doses of 100, 200, 400, and 800 mg/kg BW. The results showed that the extract met the extract standardization parameters. The extract showed antihyperuricemia activity and a dose of 800 mg/kg BW had the highest antihyperuricemia activity compared to other doses. Statistical analysis showed no significant difference (p>0.05) between the 800 mg/kg BW dose group and the positive control (allopurinol) but significantly different from the other treatment groups, but there was no significant difference (p>0.05) between the 100, 200, and 400 mg/kg BW treatment groups. The extract showed a 50% effective dose value (ED₅₀) of 398.622 mg/kg BW. Based on the results of this study, the ethanol extract of L. inermis leaves has the potential to be developed as a natural ingredient in hyperuricemia therapy. Keywords: Antihyperuricemia, Lawsonia inermis, etanol extract, Effective dose

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2507001291	T167970	T1679702025	Central Library (Reference)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T1679702025

Publisher

Indralaya : Prodi Ilmu Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam., 2025

Collation

xvii, 93 hlm.; ilus.; tab.; 29 cm.

Language

Indonesia

ISBN/ISSN

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Classification

582.120 7

Content Type

Text

Media Type

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Carrier Type

-

Edition

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Subject(s)

Tanaman Obat--Ekstrak Daun Pacar Kayu

Specific Detail Info

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Statement of Responsibility

MI

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