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UJI ANALGETIK DAN ANTI INFLAMASI EKSTRAK DAN FRAKSI DAUN SEBURO (Garcinia forbesii King.) PADA TIKUS WISTAR JANTAN

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Penilaian

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The ethanol extract of seburo leaves (Garcinia forbesii King) contains flavonoid, alkaloid, phenolic, saponin and steroid compounds which are potentially active as an analgesic and anti-inflammatory. This study aims to determine the characteristics of the extract as well as the analgesic and anti-inflammatory effects of the ethanol extract and fractions with different solvent polarities from seburo leaves based on the reduction in rat writhing from 0.6% v/v acetic acid induction and the reduction in edema volume from 1% w/v carrageenan induction. The results of the percent analgesic value for the positive control were 71.955%, ethyl acetate was 69.230, Ethanol Extract was 50.506, N-hexane was 14.102 and water ethanol was 7.692. The percent inhibition value of positive control was 73.44%, ethyl acetate was 64.10%, ethanol extract was 56.18%, N-hexane was 44.63%. This shows that the ethyl acetate fraction is the most active and optimal as an analgesic and anti�inflammatory and the resulting effect is equivalent to the positive control Na diclofenac treatment (p>0.05). Measurements were carried out using the writhing test and rat paw edema method on 24 male white Wistar rats divided into 6 treatment groups. Group I as a negative control was given Na CMC 1%, group II as a positive control was given Na diclofenac, and groups III, IV, V, and VI as test groups were given the same dose of 200 mg/kgBW with different solvent polarities, ethanol extract, n-hexane fraction, ethyl acetate fraction, and ethanol-water fraction. Key Words : Analgesic, anti-inflammatory, Garcinia forbesii King, rat paw edema, writhing test

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2507001274	T167961	T1679612025	Central Library (Reference)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T1679612025

Publisher

Indralaya : Prodi Ilmu Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam., 2025

Collation

xviii, 112 hlm.; ilus.; tab.; 29 cm.

Language

Indonesia

ISBN/ISSN

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Classification

582.120 7

Content Type

Text

Media Type

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Carrier Type

-

Edition

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Subject(s)

Tanaman Obat--Ekstrak Daun Seburo

Specific Detail Info

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Statement of Responsibility

MI

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