Skripsi

UJI ANALGETIKA DAN ANTIINFLAMASI EKSTRAK DAN FRAKSI DAUN KARDIA (Bellucia pentamera Naudin) TERHADAP TIKUS WISTAR JANTAN

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Penilaian

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The Kardia plant (Bellucia Pentamera Naudin), a member of the Melastomataceae family, contains compounds such as steroids, triterpenoids, and flavonoids, which exhibit potential analgesic and anti-inflammatory properties. This study aims to characterize the extract and evaluate its analgesic and anti-inflammatory effects based on the reduction in writhing behavior in mice and edema volume in rats treated with extracts and fractions of Kardia leaves. The analgesic and anti-inflammatory tests were conducted using the writhing test and rat hind paw edema method on 24 male Wistar rats, divided into six groups: a positive control group treated with sodium diclofenac, a negative control group treated with 1% Na CMC, and test groups (ethanol extract, n-hexane fraction, ethyl acetate fraction, and ethanol-water fraction) at a dose of 400 mg/kg body weight. The highest analgesic and anti-inflammatory activity was observed in the n-hexane fraction, which contained triterpenoid and steroid compounds. The highest analgesic percentage was recorded in the n-hexane fraction (73.74%), followed by the ethyl acetate fraction (71.74%), ethanol extract (67.99%), and ethanol-water fraction (64.16%). The n-hexane fraction group showed no significant difference compared to the positive control group (72.44%). The highest anti-inflammatory inhibition percentage was also observed in the n-hexane fraction group (51.20%), followed by the ethyl acetate fraction (50.44%), ethanol extract (50.00%), and ethanol-water fraction (41.00%). The n-hexane fraction group showed no significant difference compared to the positive control group (61.00%). Key words: Bellucia pentamera Naudin, analgesics, anti-inflammatory, writhing test, rat hind paw edema

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2507001261	T167910	T1679102025	Central Library (Reference)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T1679102025

Publisher

Indralaya : Prodi Ilmu Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam., 2025

Collation

xvi, 116 hlm.; ilus.; tab.; 29 cm.

Language

Indonesia

ISBN/ISSN

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Classification

582.120 7

Content Type

Text

Media Type

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Carrier Type

-

Edition

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Subject(s)

Tanaman Obat--Ekstrak Daun Kardia

Specific Detail Info

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Statement of Responsibility

MI

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