Skripsi

UJI AKTIVITAS PENYEMBUHAN LUKA BAKAR SUB MIKROEMULSI EKSTRAK DAUN SAMBILOTO DENGAN KOMBINASI TWEEN 80 DAN PEG-400 TERHADAP TIKUS GALUR WISTAR

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Penilaian

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Sambiloto has secondary metabolite compounds that are active as anti-inflammatory, antioxidant and antibacterial which have the potential to be developed into sub-microemulsion preparations for burns. This study aims to provide a sub-microemulsion preparation of sambiloto leaf extract (Andrographis paniculata) with a combination of Tween 80 and PEG-400 as an innovative preparation and burn activity test against the Wistar strain. This study was divided into 5 treatment groups, namely the normal control group, positive control (Tekasol), negatif control, 1% sambiloto cream and 1% sambiloto extract sub-microemulsion. Based on the evaluation results, the 1% sambiloto extract sub-microemulsion preparation had an average particle size of 97.396 ± 36.108 nm, and a polydispersity index of 0.247 ± 0.026 with an adsorption efficiency of 99.401 ± 0.002%. The results of the burn treatment test on Wistar rats obtained a positive control group of 90.60 ± 2.68%, negatif control 62.88 ± 2.30%, 1% sambiloto cream 86.47 ± 2.64% and 1% sambiloto microemulsion sub extract 92.31 ± 1.02%. Based on the results of the burn healing activity, the 1% sambiloto extract sub microemulsion group showed good wound healing results compared to the positive control. The results of the histopathology of the sub microemulsion group showed 88% tissue regeneration in the formation of new epidermis and 90% dermis tissue regeneration characterized by high fibroblasts, dominant collagen deposition and low inflammatory cells that were no different from the normal group.

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2507001220	T167754	T1677542025	Central Library (Reference)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T1677542025

Publisher

Indralaya : Prodi Ilmu Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam., 2025

Collation

xviii, 134 hlm.; ilus.; tab.; 29 cm.

Language

Indonesia

ISBN/ISSN

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Classification

582.120 7

Content Type

Text

Media Type

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Carrier Type

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Edition

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Subject(s)

Ekstrak Daun Sambiloto

Specific Detail Info

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Statement of Responsibility

MI

Other version/related

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