Skripsi

UJI SINERGISME ANTIOKSIDAN KOMBINASI DAUN PEPAYA (Carica papaya), DAUN MELINJO (Gnetum gnemon), DAN DAUN PELAWAN (Tristaniopsis merguensis) MELALUI METODE DPPH

---

Penilaian

---

Excessive free radical production can lead to oxidative stress that damages DNA, proteins and lipids, triggering serious neurodegenerative and autoimmune diseases. Oxidative damage caused by free radicals can be prevented by the activity of antioxidant compounds. Based on previous research, papaya leaves, melinjo leaves, and pelawan leaves as natural antioxidants contain flavonoids and phenolic compounds with bioactivity mechanisms that reduce free radicals. The combination of these three plants has the potential to produce higher antioxidant activity because it can produce a synergistic effect in reducing stress due to free radicals. In this study, the fractions were combined with the aim of obtaining stronger antioxidant bioactivity than the single fraction. This process was carried out by combining the active fractions tested for antioxidants through the DPPH (1,1-diphenyl-2-picrylhydrazyl) method. The results showed the best combination with synergistic interactions in melinjo ethanol fraction (IC50 41,2 µg/mL) and pelawan (IC50 5,83 µg/mL) which resulted in an IC50 value of 3,87 µg/mL, melinjo ethanol (IC50 41,3 µg/mL) and papaya (IC50 106,73 µg/mL) which resulted in an IC50 value of 16, 02 µg/mL, ethyl acetate melinjo (IC50 101,22 µg/mL) and papaya (IC50 113,79 µg/mL) which produced an IC50 value of 21,74 µg/mL and a combination of n-hexane melinjo (IC50 157,16 µg/mL) with papaya (IC50 178,27 µg/mL) which produced an IC50 value of 120,54 µg/mL. Based on the test results, it can be seen that the combination of plants with synergistic effects showed stronger antioxidant activity than the antioxidant activity of plants produced singly.

---

Availability

Inventory Code	Barcode	Call Number	Location	Status
2507000339	T164859	T1648592025	Central Library (Reference)	Available but not for loan - Not for Loan

Detail Information

Series Title

-

Call Number

T1648592025

Publisher

Indralaya : Prodi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya., 2025

Collation

xix, 107 hlm.; ilus.; tab.; 29 cm.

Language

Indonesia

ISBN/ISSN

-

Classification

582.120 7

Content Type

Text

Media Type

-

Carrier Type

-

Edition

-

Subject(s)

Tanaman herbal
Daun pepaya
Prodi Farmasi
Daun Melinjo
Daun Pelawan

Specific Detail Info

-

Statement of Responsibility

MI

Other version/related

File Attachment

Comments

---

You must be logged in to post a comment