Skripsi

UJI AKTIVITAS PENYEMBUHAN LUKA BAKAR DAN LUKA SAYAT DARI EKSTRAK ETANOL DAUN PACAR KUKU (Lawsonia inermis L.) TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR

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Penilaian

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Lawsonia inermis is a traditional medicinal plant used to treat inflammation of the finger joints and skin diseases.The aims of This study were evaluated the efficacy of Lawsonia inermis leaf extract in healing burn and incision wounds. The extraction was carried out using the maceration method with ethanol solvent.The research were used 60 male Wistar rats, divided into six treatment groups (five rats per group): positive control (1% silver sulfadiazine ointment), negative control and four treatment groups with ointment concentrations of 2.5%, 5%, 7.5%, and 10% containing adeps lanae and white petrolatum. Burn wounds were created using a heated metal plate, while incision wounds were made with a sterile scalpel 3 cm in length. Observed parameters included burn area, incision length, percentage of healing, and skin histopathology.The results showed that the treatment group concentration was the most effective concentration, achieving 100% healing for burn wounds within 12 days, and the 2.5% concentration achieved 100% healing for incision wounds within 5 days. The treatment groups showed significantly different (p0.05) compared to the positive control. Histopathological analysis showed epithelial thickness of 45.54 µm and collagen thickness of 607.09 µm for burn wounds, while for incision wounds with 5% concentration, the epithelial thickness was 65.02 µm and collagen thickness 828.03 µm negative control: 16.76 µm and 350.14 µm).This data indicated the ethanol extract of Lawsonia inermis leaves at a 5% concentration can accelerate the healing of burn and incision wounds.

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2507000065	T163840	T1638402024	Central Library (Reference)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T1638402024

Publisher

Indralaya : Prodi Ilmu Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam., 2025

Collation

xvi, 103 hlm.; ilus.; tab.; 29 cm.

Language

Indonesia

ISBN/ISSN

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Classification

582.120 7

Content Type

Text

Media Type

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Carrier Type

-

Edition

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Subject(s)

Prodi Ilmu Farmasi Universitas Sriwijaya
Tanaman Herbal--Daun Pacar Kuku

Specific Detail Info

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Statement of Responsibility

MI

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