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UJI TOKSISITAS AKUT EKSTRAK ETANOL DAUN SUKUN (ARTOCARPUS ALTILITIS (PARK.) FOSBERG) TERHADAP TIKUS PUTIH BETINA GALUR WISTAR DENGAN ACUTE TOXIC CLASS METHOD

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Penilaian

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Breadfruit leaves (Artocarpus altilitis) are one of the herbal medicines that have activity as antihyperglycemia, antibacterial, anti-inflammatory, and antihypertensive. From the results of phytochemical screening, it is known that ethanol extract of breadfruit leaves contains phenolics, saponins, tannins, flavanoids, polyphenols, hydrocyanic acid, acetylcholine, riboflavin. The safety of using breadfruit leaves as a natural medicinal preparation must be supported by scientific research on toxicity testing. In this study, an acute toxicity test of ethanol extract of breadfruit leaves was carried out on female Wistar rats using the Acute Toxic Class Method. In this method, preliminary tests were carried out to obtain the initial dose used in the main test. Based on preliminary tests, a dose of 10,000 mg/kgBB was obtained as the initial dose for the main test. The results of observations in the main test group showed no deaths in the test animals which indicated that there was no toxic effect from EEDS. This is reinforced based on the examination of biochemical parameters obtained the results of no significant differences in the levels of SGOT, SGPT, ureum, LDL, and Trigriserida (p>0.05), but there is a significant difference in creatinine levels (p

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2507000113	T164134	T1641342024	Central Library (REFERENCE)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T1641342024

Publisher

Indralaya : Prodi Ilmu Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam., 2024

Collation

xvi, 57 hlm.; 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

615.407

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Farmasi

Specific Detail Info

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Statement of Responsibility

EM

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