Skripsi

STUDI IN SILICO POTENSI SENYAWA PADA DAUN SIRIH (Piper betle L.) SEBAGAI AGEN ANTIHIPERLIPIDEMIA DENGAN PENDEKATAN NETWORK PHARMACOLOGY DAN MOLECULAR DOCKING

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Penilaian

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Hyperlipidemia is characterized by increased normal levels of plasma lipids such as cholesterol, triglycerides, cholesterol esters, phospholipids, and sometimes plasma lipoproteins, including very low-density lipoproteins (VLDL) and low-density lipoproteins (LDL), along with decreased high-density lipoproteins (HDL). This study used an in silico approach to predict the molecular potential of betel leaf (Piper betle L.) target compounds for antihyperlipidemia activity. Potential compounds of betel leaf include 4H-Pyran-4-one, 2,3-dihydro-3,5-dihydroxy-6-methyl, 13-hexyl-oxa-cyclotridec-10-en-2-one, Cyclopropaneoctanoic acid, 9,11-Octadecadienoic acid, methyl ester, Linoleic acid chloride, (Z)6, (Z)9-Pentadecadien-1-ol, and ethanol, 2-(9,12-octadecadienyloxy). SwissADME and pkCSM evaluate and optimize the ADME/Tox profile of compounds and rely on experimental data. The Swiss ADME database predicts drug similarities of all active compounds of leaves that meet the Lipinski rules. STRING and Cytoscape will build and analyze complex relationships between compounds, targets, and pathways. The Cytoscape database with the Cluego plug-in analyzed GO and KEGG enrichment to obtain six hub genes associated with hyperlipidemia. Validation is considered valid if the RMSD value is less than 2 Å, the binding affinity value is low, it is in the same binding pocket, and it has the same amino acid residues as the original ligand. Visualization of the unity of docking results shows the docking result of 13-hexyl-oxa-cyclotridec-10-en-2-one with the 6WZM receptor has the lowest binding affinity value of -4.9 kcal/mol, is in the same binding pocket, and has the same amino acid residues as the original ligand.

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2407000831	T139121	T1391212024	Central Library (References)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T1391212024

Publisher

Inderalaya : Prodi Ilmu Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam., 2024

Collation

xvi, 158 hlm.; ilus.; ttab.; 29 cm.

Language

Indonesia

ISBN/ISSN

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Classification

582.120 7

Content Type

Text

Media Type

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Carrier Type

-

Edition

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Subject(s)

Tumbuhan obat
Prodi Ilmu Farmasi
Senyawa Daun Oregano

Specific Detail Info

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Statement of Responsibility

MI

Other version/related

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