Skripsi

OPTIMASI KONSENTRASI CREMOPHOR RH 40 DAN ETANOL 96% DALAM FORMULASI SEDIAAN NANOEMULSI EKSTRAK ETANOL DAUN SUKUN (Artocarpus altilis (Parkinson) Fosberg)

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Penilaian

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Breadfruit leaves (Artocarpus altilis (Parkinson) Fosberg) contain the main flavonoid compound in the form of quercetin which has potential as an antiosteoarthritis. Nanoemulsion preparation is carried out to increase drug stability and penetration. This research aims to determine the optimum concentration of Cremophor RH 40 and Ethanol 96% using the factorial 22. The optimum formula is determined based on pH value, density, viscosity, percent transmittance, percent total flavonoid content. The optimum formula continues with PSA, in vitro diffusion, and stability. The results showed that the optimal formula consisted of Cremophor RH 40 at a concentration of 10% and Ethanol 96% at 20%. The nanoemulsion PSA exhibited a globule size 193.566 ± 21.373 nm; PDI 0.754 ± 0,067; zeta potential -34.466 ± 0.262. In the in vitro diffusion test, the nanoemulsion preparation diffused faster than the cream preparation, indicating that the release model follows the Higuchi order. The cycling stability not experience significant changes (p

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2407001818	T141516	T1415162024	Central Library (References)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T1415162024

Publisher

Inderalaya : Prodi Ilmu Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam., 2024

Collation

xviii, 99 hlm.; tab.; 29 cm.

Language

Indonesia

ISBN/ISSN

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Classification

582.120 7

Content Type

Text

Media Type

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Carrier Type

-

Edition

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Subject(s)

Prodi Ilmu Farmasi
Ekstrak Daun Sukun

Specific Detail Info

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Statement of Responsibility

MI

Other version/related

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