Skripsi

OPTIMASI DAN KARAKTERISASI NANOEMULSI ERITROMISIN DENGAN VARIASI KONSENTRASI TWEEN 80 SEBAGAI SURFAKTAN DAN PEG-400 SEBAGAI KOSURFAKTAN MENGGUNAKAN FACTORIAL DESIGN

---

Penilaian

---

Erythromycin is a drug classified into Biopharmaceutical Classification System (BCS) class II which has low solubility in water so that it can reduce the speed of drug penetration into skin. One of the efforts to increase the penetration of Erythromycin is to formulate erythromycin into a nanoemulsion delivery system. The nanoemulsion was prepared by the PIT (Phase Transition Temperature) method which is a development of the spontaneous emulsification and low energy stirring methods, then using ultraturrax to reduce droplet size and ultrasonication to maintain droplet size. This study aims to find the optimum formula of Erythromycin nanoemulsion with varying concentrations of Tween 80 and PEG 400 as surfactant and cosurfactant using Design Expert software with Factorial design 22 method. The optimum formula was determined based on the results of organoleptic test characterization, entrapment efficiency (%EE), percent transmittance, viscosity test, pH test, density, and stability test. The optimum formula selected based on the system is a nanoemulsion that has a concentration of tween 80 25% and PEG 400 25% which has a desirability value

---

Availability

Inventory Code	Barcode	Call Number	Location	Status
2407000511	T138547	T1385472024	Central Library (References)	Available but not for loan - Not for Loan

Detail Information

Series Title

-

Call Number

T1385472024

Publisher

Inderalaya : Prodi Ilmu Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam., 2024

Collation

xvii, 119 hlm.; ilus.; 29 cm.

Language

Indonesia

ISBN/ISSN

-

Classification

615.107

Content Type

Text

Media Type

-

Carrier Type

-

Edition

-

Subject(s)

Farmakologi
Prodi Ilmu Farmasi,

Specific Detail Info

-

Statement of Responsibility

MI

Other version/related

File Attachment

Comments

---

You must be logged in to post a comment