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OPTIMASI FORMULA NANOSTRUCTURED LIPID CARRIER EKSTRAK KULIT JERUK MANIS (Citrus sinensis L.) DENGAN METODE CENTRAL COMPOSITE DESIGN

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Penilaian

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The utilization of sweet orange peel is still minimal as it is often overlooked after fruit processing for consumption, despite being rich in bioactive compounds, including flavonoids, especially for topical preparations. Previous research has mainly focused on conventional formulations with limitations in skin penetration. The Nanostructured Lipid Carrier (NLC) delivery system can enhance percutaneous penetration. This study aimed to optimize the NLC formula of sweet orange peel extract based on viscosity, pH, particle size, zeta potential, mobility, and polydispersity index (PDI) characteristics. The design and optimization of the formula used central composite design with variations in the concentration of solid lipid monostearin and liquid lipid oleic acid, employing a high-speed homogenization method. The optimum formula underwent a physical stability test (cycling test) and morphology observation using TEM. The optimum formula was obtained with 3% monostearin and 11.372% oleic acid concentrations. The characteristics of the resulting optimum NLC formula included pH of 6.30±0.001, which is non-irritating to the skin, viscosity of 571.1±15.41 cps, zeta potential of -26.54±0.889 m/V, mobility of 1.1156±0.1443 mS/cm, small particle size of 367.5±1.858 nm, and PDI value of 0.3373±0.00979, indicating particle size uniformity. The physical stability results showed no changes over 6 cycles. The observed NLC morphology was spherical. Based on the obtained results, the optimum NLC formula of sweet orange peel extract demonstrated good characterization and stability.

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2407001348	T140030	T1400302023	Central Library (References)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T1400302023

Publisher

Inderalaya : Prodi Ilmu Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam., 2024

Collation

xix, 103 hlm.; ilus.; tab.; 29 cm.

Language

Indonesia

ISBN/ISSN

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Classification

582.120 7

Content Type

Text

Media Type

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Carrier Type

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Edition

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Subject(s)

Tanaman obat
Prodi Ilmu Farmasi
Ekstrak Kulit Jeruk Manis

Specific Detail Info

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Statement of Responsibility

MI

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