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UJI AKTIVITAS ANTIDEPRESAN EKSTRAK ETANOL DAUN CEMPEDAK (Artocarpus champeden) TERHADAP MENCIT (Mus musculus)

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Cempedak (Artocarpus champeden) leaves contain flavonoids that are efficacious as antioxidants which are thought to have potential as antidepressant activity. This study aims to determine the effect of cempedak leaf ethanol extract as an antidepressant and find out the best concentration of cempedak leaf ethanol extract as an antidepressant. Parameters observed included length of fall, immobility time, line crossings, weight changes, and sucrose consumption. The rats were divided into 6 groups namely, normal group (NaCMC 1% without acute stress induction), negative group (NaCMC 1% with acute stress induction), positive group (fluoxetine 20 mg/kg BW), and treatment group I, II, and III (ethanol extract cempedak leaves with doses of 100, 200, 400 mg/kg BW, respectively). Antidepressant testing of each group was carried out for 35 days. Measurement of traction test, tail suspension test, forced swimming test, and locomotor parameters was carried out on days 1, 7, and 14, while weight measurement was carried out on days 0, 5, 10, 15, 20, and measurement of the amount of sucrose. The results showed ethanol extract of cempedak leaves had antidepressant activity in mice induced by acute stress, compared to negative controls (p

Availability
Inventory Code Barcode Call Number Location Status
24070027792407002779T1440172024Central Library (references)Available but not for loan - Not for Loan
Detail Information
Series Title
-
Call Number
T1440172024
Publisher
Indralaya : Prodi Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya.,
Collation
xvii, 99 hlm.; ilus.; tab.; 28cm
Language
Indonesia
ISBN/ISSN
-
Classification
580.707
Content Type
Text
Media Type
unmediated
Carrier Type
unspecified
Edition
-
Subject(s)
Jurusan Farmasi
ANTIDEPRESAN
Specific Detail Info
-
Statement of Responsibility
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