Skripsi

STUDI SISTEM DISPERSI PADAT ASAM MEFENAMAT DENGAN KOMBINASI KITOSAN DAN NA-ALGINAT SECARA BEAD MILLING DENGAN VARIASI JUMLAH KITOSAN

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Penilaian

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Mefenamic acid is a drug included in the biopharmaceutical classification system (BCS) class II so it is difficult to dissolve water which is overcome by making it into a solid dispersion. The combination of chitosan and sodium alginate is used as a carrier substance in solid dispersion. This study aims to determine the effect of chitosan and sodium alginate as a carrier on the dissolution rate of mefenamic acid solid dispersion. The bead milling method was chosen because it is easy to work with, affordable, and environmentally friendly. Three mefenamic acid solid dispersion formulations were made with varying amounts of chitosan. Evaluation and characterization of mefenamic acid solid dispersion samples were conducted through XRD, FTIR, SEM, solubility test, and dissolution test. The test results showed a decrease in the crystalline degree of mefenamic acid, no formation of new functional groups, changes in the morphology of the solid dispersion, solubility of the solid dispersion in the SIF solution, and an increase in the dissolution rate of mefenamic acid in the solid dispersion. Based on the test results, it can be concluded that the preparation of mefenamic acid solid dispersion by bead milling method can increase the solubility and dissolution rate of mefenamic acid.

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2407001174	T138865	T1388652024	Central Library (References)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T1388652024

Publisher

Inderalaya : Prodi Ilmu Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam., 2024

Collation

xix, 80 hlm.; ilus.; tab.; 29 cm.

Language

Indonesia

ISBN/ISSN

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Classification

615.107

Content Type

Text

Media Type

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Carrier Type

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Edition

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Subject(s)

Prodi Ilmu Farmasi
Farmakologi--Asam Mefenamat

Specific Detail Info

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Statement of Responsibility

MI

Other version/related

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