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Image of OPTIMASI DAN KARAKTERISASI NANOEMULSI ERITROMISIN DENGAN VARIASI KONSENTRASI ZAT AKTIF DAN VIRGIN COCONUT OIL (VCO) MENGGUNAKAN METODE DESAIN FAKTORIAL

Skripsi

OPTIMASI DAN KARAKTERISASI NANOEMULSI ERITROMISIN DENGAN VARIASI KONSENTRASI ZAT AKTIF DAN VIRGIN COCONUT OIL (VCO) MENGGUNAKAN METODE DESAIN FAKTORIAL

Insiratu, Deanova - Personal Name;

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Penilaian anda saat ini :  

Erythromycin belongs to Biopharmaceutical Classification System (BCS) class 2, indicating limited solubility, which in turn results in restricted penetration and effectiveness.Incorporating erythromycin into a nanoemulsion delivery system can be a promising approach to overcome its limitations. This study aims to find the optimum formula for erythromycin nanoemulsion with variations in the concentration of the active substance and Virgin Coconut Oil (VCO) as the oil phase, using Design Expert software with a factorial design method 22 . Erythromycin nanoemulsion was created using a combination of high-energy process methods. The optimal formula was determined based on the highest desirability value with the best characterization results, including %EE (%Encapsulation Efficiency), %transmitance, viscosity, pH, density, and stability tests. System optimization results indicated that the optimum concentrations of erythromycin and VCO were 2% and 5%, respectively. Characterization of the optimum formula of erythromycin nanoemulsion resulted in a particle Size of 143.833 ± 3.083 nm, a polydispersity index value of 0.368 ± 0.00, and a zeta potential of -16.05 mV ± 0.00. The optimum formula of erythromycin nanoemulsion also demonstrated good physical stability based on cycling and centrifugation test results, with no phase separation and significant pH changes. Based on the results obtained, the optimum formula of erythromycin nanoemulsion has good characterization and stability results in accordance with the literature.


Availability
Inventory Code Barcode Call Number Location Status
2407000510T138534T1385342024Central Library (References)Available but not for loan - Not for Loan
Detail Information
Series Title
-
Call Number
T1385342024
Publisher
Inderalaya : Prodi Ilmu Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam., 2024
Collation
xix, 102 hlm.; ilus.; 29 cm.
Language
Indonesia
ISBN/ISSN
-
Classification
615.107
Content Type
Text
Media Type
-
Carrier Type
-
Edition
-
Subject(s)
Prodi Ilmu Farmas
Farmakologi--VCO
Specific Detail Info
-
Statement of Responsibility
MI
Other version/related

No other version available

File Attachment
  • OPTIMASI DAN KARAKTERISASI NANOEMULSI ERITROMISIN DENGAN VARIASI KONSENTRASI ZAT AKTIF DAN VIRGIN COCONUT OIL (VCO) MENGGUNAKAN METODE DESAIN FAKTORIAL
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