Skripsi

PREPARASI DAN KARAKTERISASI TRANSDERMAL PATCH EKSTRAK KULIT MANGGIS (Garcinia mangostana L.) TERPURIFIKASI 90% ALFA MANGOSTIN DENGAN VARIASI KONSENTRASI SORBITOL

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Penilaian

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Mangosteen peel extract has an alfa-mangosteen compound that can accelerate cell healing by stimulating fibroblast growth, thus providing effects as an anti�inflammatory and antimicrobial. The choice of transdermal patch dosage form for mangosteen peel extract aims to effectively deliver active substances through the skin to reach the systemic. The purpose of this study was to obtain a formula with the best plasticizer concentration in the transdermal patch preparation of mangosteen peel extract on open wound healing. Patches were made by using the solvent coasting method in 3 formulas namely FI, FII, and FIII with variations in sorbitol concentration of 10%, 15%, and 20%. The best formula result obtained 20% sorbitol concentration in FIII which produced patches with smooth, elastic, and transparent surfaces. In addition, the patch produced weight uniformity of 33.667 mg, thickness of 0.059 mm, percent elongation of 93,038%, swelling of 693,77%, and humidity of 3.228%. The results of the content uniformity were obtained of 100.016% ± 0,014%. The results of the stability test showed that the organoleptic characteristics produced were good, with levels produced in the 6th cycle of 100.008 organoleptically produced well after the stability test with the resulting content in the 6th cycle of 100.008% ± 0.010%. The best penetration test results produced an average cumulative % penetrated of 32.057% and J of 105.911 µg/cm-2 /h-1 . FTIR test resulted in the interaction of chitosan and sodium alginate at wave numbers 3288.56 cm-1. Based on the results of the study, it is concluded that the transdermal patch of mangosteen peel extract has good characteristics, stability, penetration of the preparation in formula III, and chemical interaction of the patch which is characterized by the presence of hydrogen bonds with high intensity.

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2407001347	T139903	T1399032024	Central Library (References)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T1399032024

Publisher

Inderalaya : Prodi Ilmu Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam., 2024

Collation

xviii, 64 hlm.; ilus.; 29 cm.

Language

Indonesia

ISBN/ISSN

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Classification

582.120 7

Content Type

Text

Media Type

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Carrier Type

-

Edition

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Subject(s)

Ekstrak Kulit Manggis
Tanaman obat
Prodi Ilmu Farmasi

Specific Detail Info

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Statement of Responsibility

MI

Other version/related

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