Skripsi

STUDI STABILITAS PROTRANSETOSOM KLINDAMISIN HCL DENGAN LIOPROTEKTAN SUKROSA MENGGUNAKAN METODE ICH Q1A (R2)

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Penilaian

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Clindamycin HCl has hydrophilic properties so if made in conventional topical formulations it has problems penetrating into the dermis layer. Transethosomes as a drug delivery system can be used in the transdermal route to increase the permeation of active substances. However, transethosomes in suspension form are still a challenge in terms of storage and stability. This study aims to overcome the stability problem of clindamycin HCl transethosomes through lyophilization with the addition of 2g/g sucrose lioprotectant to lipids so that clindamycin HCl protransethosomes are produced. The results showed that the lyophilized transethosome formula with the addition of sucrose could improve the characterization with % entrapment efficiency, particle size, PDI and zeta potential of 97.202 ± 0.140, 222.5 ± 14.58 nm, 0.353 ± 0.038, and -35.67 ± 1.332 mV, respectively. The stability results using the ICH Q1A(R2) standard showed that the release model of the lyophilized transethosomes with the addition of lioprotectant followed the first order with a better shelf life of about 227,963 days than the transethosome suspension with a shelf life of 32,566 at room temperature. The penetration test results showed that lyophilization with the addition of lioprotectant can increase the penetration rate and the zero-order release model showed sustained release. It can be concluded that the lyophilized transethosome formula with the addition of lioprotectant can improve the characterization results, shelf life of transethosomes and penetration rate.

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2407001860	T141751	T1417512024	Central Library (References)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T1417512024

Publisher

Inderalaya : Prodi Ilmu Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam., 2024

Collation

xix, 93 hlm.; ilus.; 29 cm.

Language

Indonesia

ISBN/ISSN

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Classification

547.707

Content Type

Text

Media Type

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Carrier Type

-

Edition

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Subject(s)

Prodi Ilmu Farmasi
Protransetosom Klindamisin

Specific Detail Info

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Statement of Responsibility

MI

Other version/related

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