Skripsi

UJI ANTIHIPERURISEMIA EKSTRAK ETANOL BATANG KAYU KUNING (ARCANGELISIA FLAVA TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR

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Penilaian

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Background: Hyperuricemia is describes a condition where serum uric acid levels increase above normal values. Hyperuricemia occurs due to increased production and excretion of uric acid in the kidneys. The first line of treatment for reducing uric acid levels is xanthine oxidase inhibitors, allupurinol and febuxostat. However, many people use traditional medicine derived from natural plants. One of the medicinal plants that is widely used is yellow wood root or Arcangelisia flava. This plant is capable of being antitumor, antidiabetic and antihypertensive because it contains ingredients such as terpenoids and alkaloids. Methods: This research was an in vivo experiment with a randomized prepost-test control group design using male white mice (n=25) with hyperuricemia conditions divided into 5 groups: negative control (Na-CMC), positive control (Allopurinol), and 3 levels The ethanol dose for Arcangelisia flava stems is 100 mg/kgBW, 200 mg/kgBW, and 400 mg/kgBW. Uric acid levels were measured on days 0, 4, and 7 using the uric acid reagent kit, measured using spectrophotometry and uric acid levels calculated manually using a formula. Results: Giving ethanol extract of Arcangelisia flava stems for 7 days can reduce serum uric acid levels in mice. The Anova test obtained a p value = 0.000, meaning there is a significant difference. Based on descriptive and statistical analysis, it was concluded that dose was an effective in reducing uric acid levels. Conclusion: Ethanol extract of yellow wood stem (Arcangelisia flava) can reduce serum uric acid levels in male white Wistar rats with hyperuricemia.

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2407000196	T137280	T1372802023	Central Library (Referens)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T1372802023

Publisher

Inderalaya : Prodi Pendidikan Dokter, Fakultas Kedokteran Universitas Sriwijaya., 2023

Collation

xvi, 65 hlm.; Ilus.; 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

615.307

Content Type

Text

Media Type

unmediated

Carrier Type

-

Edition

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Subject(s)

Obat-obatan organik
Prodi Pendidikan Dokter

Specific Detail Info

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Statement of Responsibility

SEPTA

Other version/related

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