Skripsi

HUBUNGAN FREKUENSI TRANSFUSI DARAH DENGAN FUNGSI HATI PADA PASIEN ANAK THALASSEMIA MAYOR DI RSMH PALEMBANG

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Penilaian

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Background: Thalassemia is a genetic condition caused by mutations in the globin gene, leading to a decrease or absence of alpha globin chains in alpha thalassemia or beta globin chains in beta thalassemia. This results in suboptimal formation of red blood cells, leading to anemia in patients, necessitating blood transfusions. Regular blood transfusions result in an excess of iron in the body. Excessive iron in the liver can lead to damage and elevate levels of SGOT and SGPT. This study aims to determine the relationship between the frequency of blood transfusions and liver function in pediatric patients with thalassemia major receiving blood transfusions at Dr. Mohammad Hoesin General Hospital in Palembang in 2022. Methods: This study used an observational analytic method with a cross sectional approach conducted by collecting secondary data from patient medical records. Samples were taken with consecutive sampling technique. The obtained data is analyzed through univariate and bivariate analysis. Results: The obtained sample consists of 85 patients, with the majority being aged ≥10 years, accounting for 69 patients (81.2%). Among them, 49 patients (57.6%) are female, 72 patients (84.7%) receive ≥10 blood transfusions per year, 56 patients (65.9%) have hemoglobin levels in the moderate anemia category, 72 patients (84.7%) have ferritin levels >2500 μg/L, 50 patients (58.8%) have abnormal SGOT levels, and 44 patients (51.8%) have abnormal SGPT levels. Based on the analysis, the frequency of blood transfusions does not have a significant relationship with SGOT levels (p = 0.829; PR = 0.875; CI 95% = 0.261-2.939) and SGPT levels (p = 0.870; PR = 0.906; CI 95% = 0.277-2.962). Conclusion: There is an insignificant relationship between the frequency of blood transfusions and liver function in pediatric patients with major thalassemia.

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2407000870	T136885	T1368852023	Central Library (Referens)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T1368852023

Publisher

Inderalaya : Prodi Pendidikan Dokter, Fakultas Kedokteran Universitas Sriwijaya., 2023

Collation

xvii, 73 hlm.; Ilus.; 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

616.150 7

Content Type

Text

Media Type

unmediated

Carrier Type

-

Edition

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Subject(s)

Thalassemia
Prodi Pendidikan Dokter

Specific Detail Info

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Statement of Responsibility

SEPTA

Other version/related

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