Skripsi

EFEK INTERMITTENT FASTING TERHADAP GAMBARAN HISTOPATOLOGI JARINGAN HEPAR

---

Penilaian

---

Background: Obesity is a condition characterized by the excessive accumulation of body fat, also the reason for insulin resistance, as lipid buildup in the liver triggers an inflammatory process. Inflammatory mediators in the liver are activated by Kupffer cells to produce cytokines pro inflammation. Prevention and management of obesity can be achieved through dietary modification intermittent fasting approach, specifically time-restricted feeding. This research aims to determine whether there are changes in the histology of liver tissue in a mice model of obesity subjected to intermittent fasting with a time-restricted feeding approach. Methods: This research used a cross-sectional method. The obtained data consisted of secondary biological material, specifically histological preparations of mice (Mus musculus) liver tissue from Muhammad Farhan's research (2023) that met the inclusion criteria. Preparations were divided into three groups based on the treatments given. Results: Successively, the number of Kupffer cells per group (cells/field of view) is 24,900 ± 10,805; 35,300 ± 10,306; and 33,020 ± 9,211. The number of steatosis per group (cells/field of view) is 0.003 ± 0.004; 0.011 ± 0.007; and 0.002 ± 0.003. The normal control group shows a significant difference in the number of Kupffer cells. The obesity group has a significant difference in the number of steatosis. Conclusion: Time-restricted feeding intermittent fasting does not have a statistically significant effect on the number of Kupffer cells in the obesity group. Time-restricted feeding intermittent fasting has a statistically significant effect on the number of steatosis in the obesity group. Keywords: Intermittent fasting, time-restricted feeding, steatosis, Kupffer cells

---

Availability

Inventory Code	Barcode	Call Number	Location	Status
2407000223	T137348	T1373482023	Central Library (Referens)	Available but not for loan - Not for Loan

Detail Information

Series Title

-

Call Number

T1373482023

Publisher

Inderalaya : Prodi Pendidikan Dokter, Fakultas Kedokteran Universitas Sriwijaya., 2023

Collation

xviii, 70 hlm.; Ilus.; 29 cm

Language

Indonesia

ISBN/ISSN

-

Classification

616.770 7

Content Type

Text

Media Type

unmediated

Carrier Type

-

Edition

-

Subject(s)

Prodi Pendidikan Dokter
Penyakit pada Jaringan Ikat

Specific Detail Info

-

Statement of Responsibility

SEPTA

Other version/related

File Attachment

Comments

---

You must be logged in to post a comment