Skripsi

POLA KEPEKAAN KLEBSIELLA PNEUMONIAE DAN ESCHERICHIA COLI PENGHASIL EXTENDED SPECTRUM β-LACTAMASE DAN RESISTEN KARBAPENEM PADA PASIEN RAWAT INAP DI RSUP DR. MOHAMMAD HOESIN PALEMBANG PERIODE JULI 2022-JUNI 2023

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Penilaian

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Background: Klebsiella pneumoniae and Escherichia coli are Gram-negative bacteria from the Enterobacteriaceae family which cause many infections, both hospital-acquired infections (HAIs) and community-acquired infections. The prevalence of resistance to these bacteria is increasing, including resistance to carbapenems and broad-spectrum cephalosporins. Resistance to antibiotics complicates therapy and increases mortality. This study aims to determine the sensitivity pattern of K. pneumoniae and E. coli producing ESBL and carbapenem resistance to antibiotics. Method: This research is a descriptive observational study with a cross-sectional design using laboratory data and medical record data period of July 2022-June 2023 at the Central Laboratory Installation and Medical Record Installation of RSUP Dr. Mohammad Hoesin Palembang which met the inclusion criteria and do not meet the exclusion criteria. Data were analyzed using Microsoft Office Excel 2019 and the IBM Statistical Package for Social Sciences (SPSS) version 22 statistical program and presented in the form of tables and narratives. Result: There were 587 K. pneumoniae isolates and 506 E. coli isolates producing ESBL or carbapenem-resistant. Prevalence of K. pneumoniae and E. coli in RSUP Dr. Mohammad Hosein Palembang, namely ESBL-K. pneumoniae (53.6%), ESBL-E. coli (72.1%), CRE-K. pneumoniae (8%), CRE-E. coli (1.8%), ESBL-CRE-K. pneumoniae (2%), and ESBL-CRE-E. coli (1%). Based on the susceptibility pattern, ESBL-producing isolates were sensitive to antibiotics from the carbapenem group, amikacin, nitrofurantoin, and tigecycline. The CRE isolate was sensitive to amikacin, nitrofurantoin, and tigecycline. ESBL-CRE isolates were sensitive to amikacin and tigecycline. Conclusion: The most prevalent ESBL-producing or carbapenem-resistant Enterobacteriaceae isolates in RSUP Dr. Mohammad Hoesin Palembang for the period July 2022-June 2023 was ESBL-E. coli (72.1%), which was sensitive to piperacillin/tazobactam, carbapenems, amikacin, nitrofurantoin, and tigecycline. Keyword: Klebsiella pneumoniae, Escherichia coli, ESBL, CRE

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2407000868	T135335	T1353352023	Central Library (Referens)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T1353352023

Publisher

Inderalaya : Prodi Pendidikan Dokter, Fakultas Kedokteran Universitas Sriwijaya., 2023

Collation

xx, 123 hlm.; Ilus.; 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

616.240 7

Content Type

Text

Media Type

unmediated

Carrier Type

-

Edition

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Subject(s)

pneumonia
Prodi Pendidikan Dokter

Specific Detail Info

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Statement of Responsibility

SEPTA

Other version/related

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