Skripsi

INTERAKSI SENYAWA KUERSETIN DARI TANAMAN KARAMUNTING (RHODOMYRTUS TOMENTOSA) DENGAN INTERLEUKIN-6 (IL-6) PADA DIABETES MELITUS TIPE 2: ANALISIS BIOINFORMATIK.

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Penilaian

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Background : Indonesia was ranked 5th worldwide regarding diabetic patients with a total number of 19,5 millions, and is expected to increase by around 21.3 millions by 2045. 90% of the case is a Type 2 Diabetes Mellitus that were caused by insulin resistance, which can be triggered by IL-6. Karamunting (Rhodomyrtus tomentosa) is a plant that often be used as a herbal medicine. Quercetin is one of many compounds found in Karamunting with medical properties such as anti-inflammatory and antioxidant. The advancements of the bioinformatic field facilitates the drug development field also. This study aims to determine how bioinformatically the potential target of quercetin compounds from the Karamunting plant (Rhodomyrtus tomentosa) and its interaction with the cytokine IL-6 which plays a role in one of the pathogenesis of insulin resistance. Methods : The research method used in this research is descriptive explorative with pre-experimental in silico design. Result : Based on the prediction result of Lipinski's rule of five, quercetin met all the criteria of druglikeness. The docking result shown that the binding affinity of quercetin and Tnf-a complex was -7.1 kcal/mol, which is lower than the native ligand that is around -3.8 kcal/mol. It is shown by the docking visualization that quercetin had a little resemblances in the amino acid residues interaction compared to that of the native ligand. Conclusion : The molecular docking result has shown that quercetin does have a lower binding affinity than the native ligand, but the interaction results were not so similar. Nevertheless, quercetin still had the potential to be developed as a IL-6 blocker. Quercetin also passed the druglikeness test so that it has the potential to be an oral medicine

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2407000840	T137923	T1379232023	Central Library (Referens)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T1379232023

Publisher

Inderalaya : Prodi Pendidikan Dokter, Fakultas Kedokteran Universitas Sriwijaya., 2023

Collation

viii, 75 hlm.; Ilus.; 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

616.460 7

Content Type

Text

Media Type

unmediated

Carrier Type

-

Edition

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Subject(s)

Diabetes Mellitus
Prodi Pendidikan Dokter

Specific Detail Info

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Statement of Responsibility

SEPTA

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