Skripsi

UJI ANTIHIPERURISEMIA EKSTRAK ETIL ASETAT BATANG KAYU KUNING (ARCANGELISIA FLAVA) TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR

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Penilaian

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Background: Stem of yellow wood (Arcangelisia flava) is a plant that are efficacious as an antihyperuricemic. This is because it contains secondary metabolites in the form of alkaloids, flavonoids, terpenoids, and tannins. Previous research conducted in vitro research on ethyl acetate extract from stem of the yellow wood (Arcangelisia flava) which has been proven to be antihyperuricemic. This study tested the antihyperuricemic effect of ethyl acetate extract from stem of the yellow wood (Arcangelisia flava) on male white Wistar rats Methods: In vivo experimental research with a randomized prepost-test control group design using male white rats (n = 25) in hyperuricemia conditions divided into 5 groups: negative control (Na-CMC), positive control (Allopurinol), and 3 dose levels of ethyl acetate extract from stem of the yellow wood (Arcangelisia flava), namely 100 mg/kg BW, 200 mg /kg BW, and 400 mg /kg BW. Uric acid levels were measured on the 0th, 4th, and 7th. The uric acid concentration was calculated manually using a formula Results: Giving ethyl acetate extract from stem of the yellow wood (Arcangelisia flava) dose I (100 mg/kg BW), dose II (200 mg/kg BW), and dose III (400 mg/kg BW) for 7 days can reduce serum uric acid levels in rats. Based on statistical analysis, it was found that ethyl acetate extract from stem of the yellow wood (Arcangelisia flava)can reduce uric acid levels by more than 50%. Thus, administering the smallest dose namely dose I (100 mg/kg BW) has the potential to reduce serum uric acid levels. Conclusion: ethyl acetate extract from stem of yellow wood (Arcangelisia flava) can reduce serum uric acid levels in hyperuricemic conditioned wistar male white rats. Keywords: Arcangelisia flava, antihyperuricemic, xanthine oxidase inhibitors, serum uric acid

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2307006799	T134439	T1344392023	Central Library (Referens)	Available but not for loan - Not for Loan

Detail Information

Series Title

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Call Number

T1344392023

Publisher

Inderalaya : Prodi Pendidikan Dokter, Fakultas Kedokteran Universitas Sriwijaya., 2023

Collation

xviii, 98 hlm.; Ilus.; 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

619.907

Content Type

Text

Media Type

unmediated

Carrier Type

-

Edition

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Subject(s)

Prodi Pendidikan Dokter
Kedokteran Eksperimental pada Mamalia dan Manusia

Specific Detail Info

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Statement of Responsibility

SEPTA

Other version/related

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