Image of PREPARASI DAN UJI AKTIVITAS ANTIBAKTERI SUBMIKRO PARTIKEL EKSTRAK DAUN KELOR (MORINGA OLEIFERA LAMK.) DENGAN VARIASI KONSENTRASI KALSIUM KLORIDA TERHADAP BAKTERI STAPHYLOCOCCUS AUREUS

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PREPARASI DAN UJI AKTIVITAS ANTIBAKTERI SUBMIKRO PARTIKEL EKSTRAK DAUN KELOR (MORINGA OLEIFERA LAMK.) DENGAN VARIASI KONSENTRASI KALSIUM KLORIDA TERHADAP BAKTERI STAPHYLOCOCCUS AUREUS

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Kelor leaf has antibacterial activity because contains quercetin which is effective against the growth of Staphylococcus aureus. This study aims to determine the variation in calcium chloride concentration as a crosslinker the submicro particles produced, to increase stability and determine its antibacterial activity submicro particles. Manufacture of submicro particles using the ionic gelation method by dispersing kelor leaf extract in a chitosan solution, then drop by drop sodium alginate and calcium chloride 20 µL; 40 µL; and 100 µL. The best formula will be determined based on the highest %EE value, then particle characterization and stability test using the heating-cooling cycle method. Kelor leaf extract contains several secondary metabolite including flavonoids, phenolics, tannins, saponins, and alkaloids. The total flavonoid content of kelor leaf extract was 31,714 mg QE/g extract. The best formula (F2) of submicro particles has %EE 84,514% with characterization of particle size 347,6 nm; PDI value 0,253; and zeta potential +21 mV. The results of the stability test F2 with a percentage reduction of 4,648%. F2 antibacterial activity against Staphylococcus aureus by disc diffusion method with inhibitory zone diameter of 22,33 ± 1,53 (strong category). It can be concluded that submicro particles of kelor leaf extract have good characterization and stability, and it has strong antibacterial activity with category ≥ 21 mm.

Availability
Inventory Code Barcode Call Number Location Status
2307004844T126229T1262292023Central Library (Referens)Available but not for loan - Not for Loan
Detail Information
Series Title
-
Call Number
T1262292023
Publisher
Indralaya : Jurusan Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya.,
Collation
xix, 100 hlm.; Ilus.; 29 cm
Language
Indonesia
ISBN/ISSN
-
Classification
615.407
Content Type
-
Media Type
-
Carrier Type
-
Edition
-
Subject(s)
Jurusan Farmasi
Farmasi Praktis
Specific Detail Info
-
Statement of Responsibility
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