Skripsi

UJI TOKSISITAS AKUT FRAKSI ETANOL DAUN KERSEN (Mutingia calabura L.) TERHADAP TIKUS JANTAN GALUR WISTAR DENGAN METODE FIXED DOSE PROCEDURE

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Penilaian

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Kersen (Mutingia calabura L.) leaves have pharmacological effect as antioxidant, antibacterial, anti-inflammatory, antihyperuricemia, antiobesity, antidiarhheal, antihyperlipidemic, analgesic, anthelmintic. Kersen leaves contain secondary metabolites, alkaloid, flavonoid, tannin, saponin, steroids. High flavonoid compounds require toxicity testing. This study aimed to determine the acute toxicity of ethanol fraction of Mutingia calabura L. leaves in vivo on Wistar strain male white rats by using fixed dose procedure method. In this study, 2 tests were carried out, the preliminary test and the main test (2 groups, normal & treatment at a dose of 2,000 mg/KgBW).The result of total flavonoid content in the ethanol fraction of kersen leaves is 139,50 mg QE/g or 13,95%. The result of observation in the main test showed that were no deaths or toxic symtomps in the test animal. Average level of biochemical parameters of normal group are SGOT 135,203  20,569 U/L, SGPT 86,372  12,604 U/L, creatinine 0,604  0,062 mg/dL, ureum 38,73  4,176 mg/dL whereas the dosage group of 2.000 mg/KgBB are SGOT 127,752  20,376 U/L, SGPT 75,576  8,406 U/L, creatinine 0,55  0,0616 mg/dL, ureum 36,916  2,257 mg/dL. A single dose of the ethanol fraction of cherry leaves at a dose of 2,000 mg/KgBW had no effect on the biochemical parameters of liver, heart, kidney and macroscopic functions of the liver, kidney and heart.

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2307003521	T105092	T1050922023	Central Library (Referens)	Available

Detail Information

Series Title

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Call Number

T1050922023

Publisher

Indralaya : Jurusan Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya., 2022

Collation

xx, 101 hlm.; Ilus.; 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

615.307

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Jurusan Farmasi
Obat-obatan organik

Specific Detail Info

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Statement of Responsibility

PITRIA

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