Image of OPTIMASI KECEPATAN DAN LAMA PENGADUKAN TERHADAP KARAKTERISASI ETOSOM KLINDAMISIN HCL DENGAN METODE ULTRA TURRAX SERTA UJI STABILITAS METODE ICH Q1A(R2)

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OPTIMASI KECEPATAN DAN LAMA PENGADUKAN TERHADAP KARAKTERISASI ETOSOM KLINDAMISIN HCL DENGAN METODE ULTRA TURRAX SERTA UJI STABILITAS METODE ICH Q1A(R2)

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Clindamycin HCl has problem of penetration into the skin, only 1% to 3% of the applied dose of clindamycin HCl can be absorbed into the skin for 24 hours so that ethosomes are expected to be a delivering clindamycin HCl in penetration into the skin with the ability to fusion with skin lipids and high deformability. This study aims to optimize the ethosomes formula for clindamycin HCl with variations in stirring speed and stirring time of ultra turrax with 22 factorial design method to obtain the best ethosom characterization including entrapment efficiency, particle size, polydispersity index, and zeta potential. The optimum formula was tested for standard ICH Q1A(R2) stability using accelerated test. Stirring speed, stirring time, and the interaction both have a significant positive effect on encapsulation efficiency and particle size, but for the polydispersity index only stirring speed has a significant positive effect, while for zeta potential, stirring speed and stirring time have a significant positive value, and the interaction both have a significant negative effect. The optimum formula was obtained at stirring speed of 7,600 rpm and stirring time of 15 minutes with encapsulation efficiency percentage of 72.382 ± 0.360, a particle size of 270.8 ± 8.686 nm, a polydispersity index of 0.111 ± 0.0317, and a zeta potential of -31.21 ± 0.842 mV. The results of the stability of the Q1A(R2) standard showed that ethosomes release model followed zero order, the activation energy 4.232 cal/mol, the kinetic constant 9.897/day with a shelf life 7.293 days at 25℃±2℃ /60% RH±5% RH and shelf life at 5℃±3℃ in 8,247 days.

Availability
Inventory Code Barcode Call Number Location Status
2307000512T89040T890402023Central Library (Referens)Available
Detail Information
Series Title
-
Call Number
T890402023
Publisher
Indralaya : Jurusan Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya.,
Collation
xvi, 100 hlm.; ilus.; 29 cm
Language
Indonesia
ISBN/ISSN
-
Classification
615.407
Content Type
-
Media Type
-
Carrier Type
-
Edition
-
Subject(s)
Jurusan Farmasi
Farmasi Praktis
Specific Detail Info
-
Statement of Responsibility
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No other version available

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