Skripsi

PENGARUH PEMBERIAN ORALLY DISSOLVING FILM EKSTRAK DAUN SUNGKAI (Peronema canescens) TERHADAP SEL IMUN TIKUS PUTIH GALUR WISTAR

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Penilaian

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Peronema canescens (sungkai leaf) contains flavonoid secondary metabolites that show activity as immunostimulants. This study aims to determine the properties of Orally Dissolving Film (ODF) of sungkai leaf extract, immunomodulatory effects, macroscopic and histopathology of rat spleen. ODF was prepared using solvent casting method. Immunity parameters observed were CD4+ T cell values using PIMA analyzer and leukocytes, lymphocytes, neutrophils and monocytes using haematology analyzer. Histopathologic observation of the spleen using light microscopy with HE stain. The test animals used were male Wistar white rats with an average weight of 200 grams. The treatment was divided into 5 groups, namely normal (Feed), negative control (Placebo), positive control (Immunos), group I (0.4 mg/KgBB Extract) and group II (0.4 mg/KgBB ODF Extract). The treatment was carried out once a day for 7 days. Based on the results of the study, the evaluation results of the ODF extract properties were qualified. The results of mouse testing showed a significant increase in leukocytes in the extract and ODF extract groups (p

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2307002823	T114322	T1143222023	Central Library (Referens)	Available

Detail Information

Series Title

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Call Number

T1143222023

Publisher

Indralaya : Jurusan Farmasi, Fakultas Matematika dan Ilmu Kelautan Universitas Sriwijaya., 2023

Collation

xv, 132 hlm.; ilus.; 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

619.907

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Jurusan Farmasi
Kedokteran Eksperimental pada Mamalia dan Manusia

Specific Detail Info

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Statement of Responsibility

PITRIA

Other version/related

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