Skripsi

PENGARUH FRAKSI NONPOLAR KAYU MANIS (CINNAMOMUM BURMANNII) TERHADAP KADAR KORTISOL TIKUS PUTIH MODEL INSOMNIA.

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Penilaian

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Insomnia is a sleep disorder that reduces the quality of life. Insomnia affects the HPA Axis by increasing cortisol levels. Cinnamomum burmannii is a plant that has antiinflammatory and antioxidant activity. This study aims to determine effect of nonpolar fraction of cinnamon on cortisol levels. This study was an in vivo experimental study using a post-test only design and a control group at the Eureka Research Laboratory. Thirty male Wistar Rats were divided into six groups: normal control (Na-CMC 0,5%), negative control (PCPA), positive control (0.1 mg/KgBW estazolam), and Cinnamon Nonpolar Fraction group (CNF) 5 mg/KgBW, 10 mg/KgBW, and 20 mg/KgBW. CNF is obtained through the separating funnel method with n-hexane solvent from cinnamon simplicia macerated with 96% ethanol. Insomnia was induced in each group, except for the normal group, by intraperitoneal administration of 300 mg/KgBB p-chlorophenylalanine (PCPA) for two days. Administration of CNF and 0,5% Na-CMC was carried out with an intragastric tube for 14 days. The rats were euthanized and blood was taken from the abdominal aorta to measure cortisol levels in serum by the ELISA method. The data were analyzed using SPSS software with a statistical significance of p < 0.05. The mean cortisol levels for each group in ng/mL respectively were 30.340 ± 0.11402; 46.720 ± 0.13038; 38.340 ± 0.11402; 41.620 ± 0.13038; 33.560 ± 0.20736.; 32.640 ± 0.11402. The reduction in mean cortisol levels in the group receiving CNF was statistically significant (p

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2207005165	T84413	T844132022	Central Library (Referens)	Available

Detail Information

Series Title

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Call Number

T844132022

Publisher

Indralaya : Prodi Pendidikan Kedokteran, Fakultas Kedokteran., 2022

Collation

xviii,112 hlm.; ilus.; 29 cm

Language

ISBN/ISSN

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Classification

619.907

Content Type

Text

Media Type

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Carrier Type

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Edition

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Subject(s)

Pendidikan Kedokteran
Kedokteran Eksperimental pada Tikus Putih

Specific Detail Info

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Statement of Responsibility

MURZ

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