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PENGARUH FRAKSI NONPOLAR KAYU MANIS (Cinnamomum burmannii) TERHADAP KADAR GABA TIKUS PUTIH MODEL INSOMNIA

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Penilaian

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Background: Insomnia is a sleep disorder that adversely affects health and quality of life. Therapy using GABA-A receptor agonists has a variety of side effects. Cinnamon contains anti-inflammatory and antioxidant compounds. This study aims to determine the effect of cinnamon nonpolar fraction (CNF) on GABA levels. Methods: This study is an experimental study in vivo post-test only with a control group. Thirty male Wistar rats were divided into six treatment groups, namely the normal control group, negative control (PCPA + Na-CMC 0.5%), positive control (PCPA + estazolam 0.1 mg/kgBW), and those who received CNF doses of 5 mg/ kgBW, 10 mg/kgBW, and 20 mg/kgBW. CNF was obtained through a separation funnel method with n-hexane solvent from cinnamon simplicia that macerated with 96% ethanol. Induction of insomnia in rats was carried out by administration of p-chlorophenylalanine (PCPA) 300 mg/kgBW via intraperitoneal injection for two days. Administration of CNF and Na-CMC 0.5% was performed with intragastric sonde for 14 days. After that, the rats were euthanized and their hypothalamic tissue was taken to measure GABA levels with ELISA. All statistical analyses, whether univariate, bivariate, or univariate, were performed using IBM SPSS Statistics 26. Results: All CNF groups had higher GABA levels than negative controls. The increase in GABA levels in all groups given CNF was statistically meaningful (p val

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Availability

Inventory Code	Barcode	Call Number	Location	Status
2207005081	T84072	T840722022	Central Library (Referens)	Available

Detail Information

Series Title

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Call Number

T840722022

Publisher

Indralaya : Prodi Pendidikan Kedokteran, Fakultas Kedokteran., 2022

Collation

xviii, 112 hlm.; ilus.; 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

619.907

Content Type

Text

Media Type

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Carrier Type

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Edition

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Subject(s)

Pendidikan Kedokteran
Kedokteran Eksperimental pada Tikus Putih

Specific Detail Info

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Statement of Responsibility

MURZ

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